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Cancer cells showed weak to moderate cytoplasmic and nuclear staining. Endometrial cancers were strongly stained. Skin and gastric cancers were weakly stained or negative.
Most cancer tissues displayed strong nuclear immunoreactivity.
GENE INFORMATION
Gene name
TARDBP (HGNC Symbol)
Synonyms
ALS10, TDP-43
Description
TAR DNA binding protein (HGNC Symbol)
Entrez gene summary
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]