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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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COPS5
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

COPS5

Gene description

COP9 signalosome subunit 5

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA004845 , CAB004242
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA004845
CAB004242

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant cells showed weak to moderate cytoplasmic immunoreactivity. Several cases of prostate and testicular cancers were strongly stained.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignant cells displayed moderate to strong cytoplasmic and nuclear immunoreactivity.

GENE INFORMATION

Gene name

COPS5 (HGNC Symbol)

Synonyms

CSN5, JAB1, MOV-34, SGN5

Description

COP9 signalosome subunit 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q13.1

Chromosome location (bp)

67043079 - 67083783

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121022 (version 83.38)

Entrez gene

10987

UniProt

Q92905 (UniProt - Evidence at protein level)

neXtProt

NX_Q92905

Antibodypedia

COPS5 antibodies

PROTEIN BROWSER

COPS5-001
COPS5-006
COPS5-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COPS5-001
ENSP00000350512
ENST00000357849
Q92905 [Direct mapping]
COP9 signalosome complex subunit 5
A0A024R7W9 [Target identity:100%; Query identity:100%]
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), isoform CRA_a
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Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000338 [protein deneddylation]
GO:0000715 [nucleotide-excision repair, DNA damage recognition]
GO:0003713 [transcription coactivator activity]
GO:0003743 [translation initiation factor activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0008021 [synaptic vesicle]
GO:0008180 [COP9 signalosome]
GO:0008237 [metallopeptidase activity]
GO:0010388 [cullin deneddylation]
GO:0016579 [protein deubiquitination]
GO:0030054 [cell junction]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046328 [regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051726 [regulation of cell cycle]
GO:0070911 [global genome nucleotide-excision repair]
GO:1903894 [regulation of IRE1-mediated unfolded protein response]
GO:1990182 [exosomal secretion]
Show all
334 aa
37.6 kDa
No 0
COPS5-006
ENSP00000428586
ENST00000518747
E5RHF2 [Direct mapping]
COP9 signalosome complex subunit 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
151 aa
16.6 kDa
No 0
COPS5-010
ENSP00000429774
ENST00000517736
E5RHH5 [Direct mapping]
COP9 signalosome complex subunit 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
197 aa
22.2 kDa
No 0

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