We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Ligase THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006513 [protein monoubiquitination] GO:0008270 [zinc ion binding] GO:0016032 [viral process] GO:0016881 [acid-amino acid ligase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0019985 [translesion synthesis] GO:0032480 [negative regulation of type I interferon production] GO:0036503 [ERAD pathway] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043627 [response to estrogen] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0046596 [regulation of viral entry into host cell] GO:0046597 [negative regulation of viral entry into host cell] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:1902186 [regulation of viral release from host cell] GO:1902187 [negative regulation of viral release from host cell] GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway]
