Expression of SLC35B1 in cancer - Summary

GENERAL INFORMATION
Gene name	SLC35B1
Gene description	Solute carrier family 35, member B1
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct membranous expression in a few tissues, also highly abundant in endothelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA057418
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA057418

GENE INFORMATION
Gene name	SLC35B1 (HGNC Symbol)
Synonyms	UGTREL1
Description	Solute carrier family 35, member B1 (HGNC Symbol)
Entrez gene summary	This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Chromosome	17
Cytoband	q21.33
Chromosome location (bp)	49700943 - 49709014
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121073 (version 83.38)
Entrez gene	10237
UniProt	P78383 (UniProt - Evidence at protein level)
neXtProt	NX_P78383
Antibodypedia	SLC35B1 antibodies

PROTEIN BROWSER

SLC35B1-001	SLC35B1-007	SLC35B1-008	SLC35B1-009	SLC35B1-010	SLC35B1-012	SLC35B1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC35B1-001 ENSP00000240333 ENST00000240333	P78383 [Direct mapping] Solute carrier family 35 member B1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005459 [UDP-galactose transmembrane transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0055085 [transmembrane transport] GO:0072334 [UDP-galactose transmembrane transport] Show all	359 aa 39.5 kDa	No	9
SLC35B1-007 ENSP00000426402 ENST00000511657	D6RG34 [Direct mapping] Solute carrier family 35 member B1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	76 aa 8.4 kDa	No	0
SLC35B1-008 ENSP00000424367 ENST00000508520	D6RB73 [Direct mapping] Solute carrier family 35 member B1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	254 aa 28.3 kDa	No	5
SLC35B1-009 ENSP00000423323 ENST00000503334	D6R981 [Direct mapping] Solute carrier family 35 member B1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	227 aa 25.2 kDa	No	7
SLC35B1-010 ENSP00000426961 ENST00000514907	D6RE58 [Direct mapping] Solute carrier family 35 member B1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	187 aa 20.8 kDa	No	4
SLC35B1-012 ENSP00000427689 ENST00000515850	D6RHG0 [Direct mapping] Solute carrier family 35 member B1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	286 aa 31.5 kDa	No	5
SLC35B1-013 ENSP00000422104 ENST00000511763	D6R9G9 [Direct mapping] Solute carrier family 35 member B1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	194 aa 21 kDa	No	4