Expression of NCAPH in cancer - Summary

GENERAL INFORMATION
Gene name	NCAPH
Gene description	Non-SMC condensin I complex, subunit H
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in lymphoid reaction centers and seminiferous ducts in testis with nuclear expression in subsets of cells in bone marrow and epithelial basal cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA002647 , HPA003008
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001 Pancreatic cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002647	HPA003008

GENE INFORMATION
Gene name	NCAPH (HGNC Symbol)
Synonyms	BRRN1, CAP-H, hCAP-H
Description	Non-SMC condensin I complex, subunit H (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]
Chromosome	2
Cytoband	q11.2
Chromosome location (bp)	96335787 - 96373845
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121152 (version 83.38)
Entrez gene	23397
UniProt	Q15003 (UniProt - Evidence at protein level)
neXtProt	NX_Q15003
Antibodypedia	NCAPH antibodies

PROTEIN BROWSER

NCAPH-001	NCAPH-002	NCAPH-004	NCAPH-005	NCAPH-006	NCAPH-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCAPH-001 ENSP00000240423 ENST00000240423	Q15003 [Direct mapping] Condensin complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000796 [condensin complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007076 [mitotic chromosome condensation] GO:0016020 [membrane] GO:0051301 [cell division] Show all	741 aa 82.6 kDa	No	0
NCAPH-002 ENSP00000400774 ENST00000427946	Q15003 [Direct mapping] Condensin complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000796 [condensin complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007076 [mitotic chromosome condensation] GO:0016020 [membrane] GO:0051301 [cell division] Show all	605 aa 67.5 kDa	No	0
NCAPH-004 ENSP00000405237 ENST00000435975	C9J470 [Direct mapping] Condensin complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000796 [condensin complex] GO:0005737 [cytoplasm] GO:0007076 [mitotic chromosome condensation] Show all	608 aa 68.1 kDa	No	0
NCAPH-005 ENSP00000407308 ENST00000455200	E9PHA2 [Direct mapping] Condensin complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000796 [condensin complex] GO:0005737 [cytoplasm] GO:0007076 [mitotic chromosome condensation] GO:0051301 [cell division] Show all	730 aa 81.6 kDa	No	0
NCAPH-006 ENSP00000415162 ENST00000435349	H7C415 [Direct mapping] Condensin complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000796 [condensin complex] GO:0007076 [mitotic chromosome condensation] Show all	182 aa 20 kDa	No	0
NCAPH-007 ENSP00000401227 ENST00000456906	C9JZP1 [Direct mapping] Condensin complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000796 [condensin complex] GO:0007076 [mitotic chromosome condensation] Show all	216 aa 24 kDa	No	0