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PAPD5

GENERAL INFORMATION

Gene name

 PAPD5

Gene description

 PAP associated domain containing 5

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA042968 , HPA048225
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA042968
HPA048225

GENE INFORMATION

Gene name

 PAPD5 (HGNC Symbol)

Synonyms

 TRF4-2

Description

 PAP associated domain containing 5 (HGNC Symbol)

Entrez gene summary

Chromosome

 16

Cytoband

 q12.1

Chromosome location (bp)

 50152918 - 50235310

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121274 (version 83.38)

Entrez gene

 64282

UniProt

 Q8NDF8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NDF8

Antibodypedia

 PAPD5 antibodies

PROTEIN BROWSER
PAPD5-001
PAPD5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAPD5-001
ENSP00000396995
ENST00000436909
Q8NDF8 [Direct mapping]
Non-canonical poly(A) RNA polymerase PAPD5
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0004652 [polynucleotide adenylyltransferase activity]
GO:0005575 [cellular_component]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0006397 [mRNA processing]
GO:0007067 [mitotic nuclear division]
GO:0016779 [nucleotidyltransferase activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0071044 [histone mRNA catabolic process]
GO:0071897 [DNA biosynthetic process]
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 698 aa
75.8 kDa 		No 0
PAPD5-002
ENSP00000455837
ENST00000561678
H3BQM0 [Direct mapping]
Non-canonical poly(A) RNA polymerase PAPD5
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0016779 [nucleotidyltransferase activity]
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 588 aa
64.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.