Expression of CEP89 in cancer - Summary - The Human Protein Atlas

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CEP89

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CEP89
Gene description	Centrosomal protein 89kDa
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA039382 , HPA040056
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039382	HPA040056

GENE INFORMATION
Gene name	CEP89 (HGNC Symbol)
Synonyms	CCDC123, FLJ14640
Description	Centrosomal protein 89kDa (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.11
Chromosome location (bp)	32875925 - 32971991
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121289 (version 83.38)
Entrez gene	84902
UniProt	Q96ST8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96ST8
Antibodypedia	CEP89 antibodies

PROTEIN BROWSER

CEP89-001	CEP89-005	CEP89-006	CEP89-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEP89-001 ENSP00000306105 ENST00000305768	Q96ST8 [Direct mapping] Centrosomal protein of 89 kDa Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005758 [mitochondrial intermembrane space] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006996 [organelle organization] GO:0031513 [nonmotile primary cilium] GO:0031514 [motile cilium] GO:0035058 [nonmotile primary cilium assembly] GO:0042384 [cilium assembly] GO:0097539 [ciliary transition fiber] Show all	783 aa 89.6 kDa	No	0
CEP89-005 ENSP00000466442 ENST00000590597	A0A0C4DGP8 [Direct mapping] Centrosomal protein of 89 kDa Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		356 aa 40.2 kDa	Yes	0
CEP89-006 ENSP00000467839 ENST00000593276	K7EQI2 [Direct mapping] Centrosomal protein of 89 kDa Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		217 aa 23.9 kDa	Yes	0
CEP89-010 ENSP00000481256 ENST00000591863	A0A087WXS8 [Direct mapping] Centrosomal protein of 89 kDa Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		80 aa 9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.