Expression of PYROXD1 in cancer - Summary - The Human Protein Atlas

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PYROXD1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PYROXD1
Gene description	Pyridine nucleotide-disulphide oxidoreductase domain 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA038319 , HPA038320
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038319	HPA038320

GENE INFORMATION
Gene name	PYROXD1 (HGNC Symbol)
Synonyms	DKFZp762G094, FLJ22028
Description	Pyridine nucleotide-disulphide oxidoreductase domain 1 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	21437615 - 21471252
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121350 (version 83.38)
Entrez gene	79912
UniProt	Q8WU10 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WU10
Antibodypedia	PYROXD1 antibodies

PROTEIN BROWSER

PYROXD1-001	PYROXD1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PYROXD1-001 ENSP00000240651 ENST00000240651	Q8WU10 [Direct mapping] Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	500 aa 55.8 kDa	No	0
PYROXD1-005 ENSP00000438505 ENST00000538582	Q8WU10 [Direct mapping] Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	429 aa 48.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.