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KCNJ8

GENERAL INFORMATION

Gene name

 KCNJ8

Gene description

 Potassium channel, inwardly rectifying subfamily J, member 8

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Tissue enhanced (heart muscle, pancreas)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA031066
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, pancreas)

GENE INFORMATION

Gene name

 KCNJ8 (HGNC Symbol)

Synonyms

 Kir6.1

Description

 Potassium channel, inwardly rectifying subfamily J, member 8 (HGNC Symbol)

Entrez gene summary

 Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). [provided by RefSeq, May 2012]

Chromosome

 12

Cytoband

 p12.1

Chromosome location (bp)

 21764955 - 21775581

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121361 (version 83.38)

Entrez gene

 3764

UniProt

 Q15842 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15842

Antibodypedia

 KCNJ8 antibodies

PROTEIN BROWSER
KCNJ8-001
KCNJ8-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNJ8-001
ENSP00000240662
ENST00000240662
Q15842 [Direct mapping]
ATP-sensitive inward rectifier potassium channel 8
A0A024RAV6 [Target identity:100%; Query identity:100%]
Potassium inwardly-rectifying channel, subfamily J, member 8, isoform CRA_a
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001822 [kidney development]
GO:0005242 [inward rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007507 [heart development]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008282 [ATP-sensitive potassium channel complex]
GO:0009268 [response to pH]
GO:0010107 [potassium ion import]
GO:0015272 [ATP-activated inward rectifier potassium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017098 [sulfonylurea receptor binding]
GO:0030016 [myofibril]
GO:0032496 [response to lipopolysaccharide]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042311 [vasodilation]
GO:0042383 [sarcolemma]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043330 [response to exogenous dsRNA]
GO:0051607 [defense response to virus]
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 424 aa
48 kDa 		No 2
KCNJ8-002
ENSP00000440012
ENST00000537950
F5GY12 [Direct mapping]
ATP-sensitive inward rectifier potassium channel 8
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005242 [inward rectifier potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0010107 [potassium ion import]
GO:0015272 [ATP-activated inward rectifier potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
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 114 aa
13.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.