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PSPC1

GENERAL INFORMATION

Gene name

 PSPC1

Gene description

 Paraspeckle component 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in a majority of tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA038904
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable) and liver cancer (unfavourable).
Thyroid cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038904

GENE INFORMATION

Gene name

 PSPC1 (HGNC Symbol)

Synonyms

 FLJ10955, PSP1

Description

 Paraspeckle component 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]

Chromosome

 13

Cytoband

 q12.11

Chromosome location (bp)

 19674752 - 19783019

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121390 (version 83.38)

Entrez gene

 55269

UniProt

 Q8WXF1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXF1

Antibodypedia

 PSPC1 antibodies

PROTEIN BROWSER
PSPC1-002
PSPC1-004
PSPC1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PSPC1-002
ENSP00000343966
ENST00000338910
Q8WXF1 [Direct mapping]
Paraspeckle component 1
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Predicted intracellular proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0042382 [paraspeckles]
GO:0042752 [regulation of circadian rhythm]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048511 [rhythmic process]
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 523 aa
58.7 kDa 		No 0
PSPC1-004
ENSP00000393069
ENST00000427943
X6RDA4 [Direct mapping]
Paraspeckle component 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 248 aa
27.3 kDa 		No 0
PSPC1-201
ENSP00000481916
ENST00000619300
Q8WXF1 [Direct mapping]
Paraspeckle component 1
Show all
Predicted intracellular proteins
Transcription factors
   Yet undefined DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0042752 [regulation of circadian rhythm]
GO:0044822 [poly(A) RNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048511 [rhythmic process]
Show all
 523 aa
58.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.