Expression of A1BG in cancer - Summary - The Human Protein Atlas

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A1BG

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	A1BG
Gene description	Alpha-1-B glycoprotein
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enhanced (REH)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Positivity in plasma.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA044252 , CAB016673
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044252	CAB016673

GENE INFORMATION
Gene name	A1BG
Synonyms
Description	Alpha-1-B glycoprotein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.43
Chromosome location (bp)	58345178 - 58353499
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121410 (version 83.38)
Entrez gene	1
UniProt	P04217 (UniProt - Evidence at protein level)
neXtProt	NX_P04217
Antibodypedia	A1BG antibodies

PROTEIN BROWSER

A1BG-001	A1BG-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
A1BG-001 ENSP00000263100 ENST00000263100	P04217 [Direct mapping] Alpha-1B-glycoprotein V9HWD8 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 163pA Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0008150 [biological_process] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	495 aa 54.3 kDa	Yes	0
A1BG-004 ENSP00000470909 ENST00000600966	M0R009 [Direct mapping] Alpha-1B-glycoprotein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	306 aa 33.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.