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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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A1BG
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

A1BG

Gene description

Alpha-1-B glycoprotein

Protein class

Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (REH)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Positivity in plasma.

ANTIBODY IHC RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 2 antibodies.
HPA044252 , CAB016673
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA044252
CAB016673

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells were negative.

GENE INFORMATION

Gene name

A1BG

Synonyms

Description

Alpha-1-B glycoprotein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.43

Chromosome location (bp)

58345178 - 58353499

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121410 (version 83.38)

Entrez gene

1

UniProt

P04217 (UniProt - Evidence at protein level)

neXtProt

NX_P04217

Antibodypedia

A1BG antibodies

PROTEIN BROWSER

A1BG-001
A1BG-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

A1BG-001
ENSP00000263100
ENST00000263100
P04217 [Direct mapping]
Alpha-1B-glycoprotein
V9HWD8 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 163pA
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0008150 [biological_process]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
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495 aa
54.3 kDa
Yes 0
A1BG-004
ENSP00000470909
ENST00000600966
M0R009 [Direct mapping]
Alpha-1B-glycoprotein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
306 aa
33.5 kDa
No 0

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