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RNF2

GENERAL INFORMATION

Gene name

 RNF2

Gene description

 Ring finger protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA026803
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026803

GENE INFORMATION

Gene name

 RNF2 (HGNC Symbol)

Synonyms

 BAP-1, BAP1, DING, HIPI3, RING1B, RING2

Description

 Ring finger protein 2 (HGNC Symbol)

Entrez gene summary

 Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q25.3

Chromosome location (bp)

 185045364 - 185102608

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121481 (version 83.38)

Entrez gene

 6045

UniProt

 Q99496 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99496

Antibodypedia

 RNF2 antibodies

PROTEIN BROWSER
RNF2-001
RNF2-002
RNF2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNF2-001
ENSP00000356480
ENST00000367510
Q99496 [Direct mapping]
E3 ubiquitin-protein ligase RING2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000151 [ubiquitin ligase complex]
GO:0000278 [mitotic cell cycle]
GO:0000791 [euchromatin]
GO:0000792 [heterochromatin]
GO:0001702 [gastrulation with mouth forming second]
GO:0001739 [sex chromatin]
GO:0003682 [chromatin binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007281 [germ cell development]
GO:0008270 [zinc ion binding]
GO:0009948 [anterior/posterior axis specification]
GO:0016574 [histone ubiquitination]
GO:0016604 [nuclear body]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0021510 [spinal cord development]
GO:0031519 [PcG protein complex]
GO:0032526 [response to retinoic acid]
GO:0035102 [PRC1 complex]
GO:0035518 [histone H2A monoubiquitination]
GO:0036353 [histone H2A-K119 monoubiquitination]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071339 [MLL1 complex]
GO:0071535 [RING-like zinc finger domain binding]
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 336 aa
37.7 kDa 		No 0
RNF2-002
ENSP00000356479
ENST00000367509
Q99496 [Direct mapping]
E3 ubiquitin-protein ligase RING2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000151 [ubiquitin ligase complex]
GO:0003682 [chromatin binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0031519 [PcG protein complex]
GO:0035102 [PRC1 complex]
GO:0035518 [histone H2A monoubiquitination]
GO:0036353 [histone H2A-K119 monoubiquitination]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0071339 [MLL1 complex]
GO:0071535 [RING-like zinc finger domain binding]
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 264 aa
29.3 kDa 		No 0
RNF2-003
ENSP00000400722
ENST00000453650
X6RFN3 [Direct mapping]
E3 ubiquitin-protein ligase RING2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
Show all
 245 aa
27.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.