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CRY2

GENERAL INFORMATION

Gene name

 CRY2

Gene description

 Cryptochrome circadian clock 2

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in a majority of tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA037577
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (favourable), colorectal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Colorectal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037577

GENE INFORMATION

Gene name

 CRY2

Synonyms

Description

 Cryptochrome circadian clock 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 45847118 - 45883248

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121671 (version 83.38)

Entrez gene

 1408

UniProt

 Q49AN0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q49AN0

Antibodypedia

 CRY2 antibodies

PROTEIN BROWSER
CRY2-001
CRY2-002
CRY2-011
CRY2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRY2-001
ENSP00000406751
ENST00000443527
A0A0D2X7Z3 [Direct mapping]
Cryptochrome-2
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   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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 614 aa
68.9 kDa 		Yes 0
CRY2-002
ENSP00000397419
ENST00000417225
Q49AN0 [Direct mapping]
Cryptochrome-2
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000989 [transcription factor activity, transcription factor binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007623 [circadian rhythm]
GO:0009785 [blue light signaling pathway]
GO:0009882 [blue light photoreceptor activity]
GO:0018298 [protein-chromophore linkage]
GO:0019902 [phosphatase binding]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0032922 [circadian regulation of gene expression]
GO:0042593 [glucose homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0042754 [negative regulation of circadian rhythm]
GO:0043130 [ubiquitin binding]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0071949 [FAD binding]
GO:2000118 [regulation of sodium-dependent phosphate transport]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
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 532 aa
60.6 kDa 		No 0
CRY2-011
ENSP00000484684
ENST00000616080
Q49AN0 [Direct mapping]
Cryptochrome-2
A2I2P1 [Target identity:100%; Query identity:100%]
Cryptochrome 2 (Photolyase-like), isoform CRA_a; Growth-inhibiting protein 37; Photolyase-like cryptochrome 2
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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000989 [transcription factor activity, transcription factor binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007623 [circadian rhythm]
GO:0009785 [blue light signaling pathway]
GO:0009882 [blue light photoreceptor activity]
GO:0018298 [protein-chromophore linkage]
GO:0019902 [phosphatase binding]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0032922 [circadian regulation of gene expression]
GO:0042593 [glucose homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0042754 [negative regulation of circadian rhythm]
GO:0043130 [ubiquitin binding]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0071949 [FAD binding]
GO:2000118 [regulation of sodium-dependent phosphate transport]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
Show all
 593 aa
66.9 kDa 		Yes 0
CRY2-201
ENSP00000478187
ENST00000616623
A0A0D2X7Z3 [Direct mapping]
Cryptochrome-2
Show all
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0006606 [protein import into nucleus]
GO:0007623 [circadian rhythm]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0019915 [lipid storage]
GO:0032868 [response to insulin]
GO:0032922 [circadian regulation of gene expression]
GO:0035257 [nuclear hormone receptor binding]
GO:0042593 [glucose homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0042754 [negative regulation of circadian rhythm]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0071949 [FAD binding]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
GO:2000850 [negative regulation of glucocorticoid secretion]
Show all
 614 aa
68.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.