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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CAT

Gene description

Catalase

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HL-60)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in hepatocytes, kidney tubules and a subset of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA051282 , HPA055838 , CAB001515
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA051282
HPA055838
CAB001515

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Liver cancers, several prostate and endometrial cancers along with a few ovarian, breast and colorectal cancers weak to moderate granular cytoplasmic positivity. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular carcinomas showed moderate to strong cytoplasmic positivity while few cases endometrial cancers displayed moderate staining. Other cancer tissues were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular and cases of prostate cancer showed moderate cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

CAT

Synonyms

Description

Catalase (HGNC Symbol)

Entrez gene summary

This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]

Chromosome

11

Cytoband

p13

Chromosome location (bp)

34438925 - 34472062

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121691 (version 83.38)

Entrez gene

847

UniProt

P04040 (UniProt - Evidence at protein level)

neXtProt

NX_P04040

Antibodypedia

CAT antibodies

PROTEIN BROWSER

CAT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAT-001
ENSP00000241052
ENST00000241052
P04040 [Direct mapping]
Catalase
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species]
GO:0001649 [osteoblast differentiation]
GO:0001657 [ureteric bud development]
GO:0001666 [response to hypoxia]
GO:0001822 [kidney development]
GO:0004046 [aminoacylase activity]
GO:0004096 [catalase activity]
GO:0005102 [receptor binding]
GO:0005615 [extracellular space]
GO:0005739 [mitochondrion]
GO:0005758 [mitochondrial intermembrane space]
GO:0005764 [lysosome]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0005782 [peroxisomal matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006144 [purine nucleobase metabolic process]
GO:0006195 [purine nucleotide catabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0006979 [response to oxidative stress]
GO:0007568 [aging]
GO:0008203 [cholesterol metabolic process]
GO:0009060 [aerobic respiration]
GO:0009314 [response to radiation]
GO:0009411 [response to UV]
GO:0009636 [response to toxic substance]
GO:0009642 [response to light intensity]
GO:0009650 [UV protection]
GO:0010193 [response to ozone]
GO:0010288 [response to lead ion]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014823 [response to activity]
GO:0014854 [response to inactivity]
GO:0016020 [membrane]
GO:0016209 [antioxidant activity]
GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor]
GO:0019899 [enzyme binding]
GO:0020027 [hemoglobin metabolic process]
GO:0020037 [heme binding]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032355 [response to estradiol]
GO:0032868 [response to insulin]
GO:0033189 [response to vitamin A]
GO:0033197 [response to vitamin E]
GO:0033591 [response to L-ascorbic acid]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0046686 [response to cadmium ion]
GO:0046872 [metal ion binding]
GO:0050661 [NADP binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051262 [protein tetramerization]
GO:0051289 [protein homotetramerization]
GO:0051781 [positive regulation of cell division]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055093 [response to hyperoxia]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070542 [response to fatty acid]
GO:0071363 [cellular response to growth factor stimulus]
GO:0080184 [response to phenylpropanoid]
Show all
527 aa
59.8 kDa
No 0

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