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Moderate cytoplasmic positivity was observed in most cancers. A few cases of urothelial cancers, renal and pancreatic cancers were strongly stained.
GENE INFORMATION
Gene name
PILRB (HGNC Symbol)
Synonyms
FDFACT1, FDFACT2
Description
Paired immunoglobin-like type 2 receptor beta (HGNC Symbol)
Entrez gene summary
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function. [provided by RefSeq, Jun 2013]
GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0016021 [integral component of membrane] GO:0042288 [MHC class I protein binding]
Q9UKJ0 [Direct mapping] Paired immunoglobulin-like type 2 receptor beta
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Predicted intracellular proteins
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GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0042288 [MHC class I protein binding]
GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0016021 [integral component of membrane] GO:0042288 [MHC class I protein binding]