Expression of GJA3 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

GJA3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GJA3
Gene description	Gap junction protein, alpha 3, 46kDa
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (melanoma)
HPA (cell line):	Cell line enhanced (CAPAN-2, HL-60)
HPA (normal tissue):	Tissue enhanced (heart muscle, parathyroid gland, placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in lens.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Supported based on 1 antibody. HPA014821
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014821

GENE INFORMATION
Gene name	GJA3 (HGNC Symbol)
Synonyms	CX46, CZP3
Description	Gap junction protein, alpha 3, 46kDa (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010]
Chromosome	13
Cytoband	q12.11
Chromosome location (bp)	20138255 - 20161049
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121743 (version 83.38)
Entrez gene	2700
UniProt	Q9Y6H8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6H8
Antibodypedia	GJA3 antibodies

PROTEIN BROWSER

GJA3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GJA3-001 ENSP00000241125 ENST00000241125	Q9Y6H8 [Direct mapping] Gap junction alpha-3 protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005243 [gap junction channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005921 [gap junction] GO:0005922 [connexon complex] GO:0006810 [transport] GO:0007154 [cell communication] GO:0007267 [cell-cell signaling] GO:0007601 [visual perception] GO:0009268 [response to pH] GO:0016021 [integral component of membrane] GO:0042542 [response to hydrogen peroxide] GO:0042802 [identical protein binding] GO:0045121 [membrane raft] GO:0055085 [transmembrane transport] Show all	435 aa 47.4 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.