Expression of ADGRB2 in cancer - Summary - The Human Protein Atlas

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ADGRB2

TISSUE

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CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	ADGRB2
Gene description	Adhesion G protein-coupled receptor B2
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (SH-SY5Y, T-47d, U-2 OS)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable) and breast cancer (favourable).
Lung cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	ADGRB2 (HGNC Symbol)
Synonyms	BAI2
Description	Adhesion G protein-coupled receptor B2 (HGNC Symbol)
Entrez gene summary	This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Chromosome	1
Cytoband	p35.2
Chromosome location (bp)	31727117 - 31764893
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121753 (version 83.38)
Entrez gene	576
UniProt	O60241 (UniProt - Evidence at protein level)
neXtProt	NX_O60241
Antibodypedia	ADGRB2 antibodies

PROTEIN BROWSER

ADGRB2-001	ADGRB2-006	ADGRB2-007	ADGRB2-008	ADGRB2-009	ADGRB2-010	ADGRB2-012	ADGRB2-014	ADGRB2-016	ADGRB2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRB2-001 ENSP00000362759 ENST00000373655	O60241 [Direct mapping] Adhesion G protein-coupled receptor B2 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007422 [peripheral nervous system development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] GO:0051965 [positive regulation of synapse assembly] Show all	1584 aa 172.5 kDa	Yes	7
ADGRB2-006 ENSP00000381564 ENST00000398556	A2A3C6 [Direct mapping] Protein ADGRB2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] Show all	1500 aa 163.8 kDa	Yes	7
ADGRB2-007 ENSP00000410921 ENST00000420125	A2A3C4 [Direct mapping] Protein ADGRB2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] Show all	847 aa 92 kDa	Yes	0
ADGRB2-008 ENSP00000381550 ENST00000398542	A2A3C1 [Direct mapping] Protein ADGRB2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] Show all	1466 aa 159.9 kDa	Yes	7
ADGRB2-009 ENSP00000381555 ENST00000398547	A2A3C3 [Direct mapping] Protein ADGRB2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] Show all	1499 aa 163.4 kDa	Yes	7
ADGRB2-010 ENSP00000381548 ENST00000398538	A2A3C2 [Direct mapping] Protein ADGRB2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] Show all	1554 aa 169.2 kDa	Yes	7
ADGRB2-012 ENSP00000414758 ENST00000436464		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1 aa 0.1 kDa	No	0
ADGRB2-014 ENSP00000435397 ENST00000527361	O60241 [Direct mapping] Adhesion G protein-coupled receptor B2 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] Show all	1551 aa 169.2 kDa	Yes	7
ADGRB2-016 ENSP00000437219 ENST00000533175	E9PND1 [Direct mapping] Adhesion G protein-coupled receptor B2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		507 aa 54.6 kDa	No	0
ADGRB2-201 ENSP00000362762 ENST00000373658	O60241 [Direct mapping] Adhesion G protein-coupled receptor B2 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] Show all	1585 aa 172.7 kDa	Yes	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.