Fields »
ABOUT
HELP
BLOG
ZNF639

GENERAL INFORMATION

Gene name

 ZNF639

Gene description

 Zinc finger protein 639

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA049023 , HPA052163
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in glioma (favourable) and liver cancer (unfavourable).
Glioma p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049023
HPA052163

GENE INFORMATION

Gene name

 ZNF639 (HGNC Symbol)

Synonyms

 ANC-2H01, ZASC1

Description

 Zinc finger protein 639 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

 3

Cytoband

 q26.33

Chromosome location (bp)

 179322991 - 179338583

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121864 (version 83.38)

Entrez gene

 51193

UniProt

 Q9UID6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UID6

Antibodypedia

 ZNF639 antibodies

PROTEIN BROWSER
ZNF639-001
ZNF639-002
ZNF639-003
ZNF639-004
ZNF639-005
ZNF639-006
ZNF639-007
ZNF639-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZNF639-001
ENSP00000325634
ENST00000326361
Q9UID6 [Direct mapping]
Zinc finger protein 639
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030307 [positive regulation of cell growth]
GO:0043621 [protein self-association]
GO:0043922 [negative regulation by host of viral transcription]
GO:0043923 [positive regulation by host of viral transcription]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
Show all
 485 aa
56.1 kDa 		No 0
ZNF639-002
ENSP00000417740
ENST00000496856
Q9UID6 [Direct mapping]
Zinc finger protein 639
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030307 [positive regulation of cell growth]
GO:0043621 [protein self-association]
GO:0043922 [negative regulation by host of viral transcription]
GO:0043923 [positive regulation by host of viral transcription]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
Show all
 485 aa
56.1 kDa 		No 0
ZNF639-003
ENSP00000418766
ENST00000484866
Q9UID6 [Direct mapping]
Zinc finger protein 639
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030307 [positive regulation of cell growth]
GO:0043621 [protein self-association]
GO:0043922 [negative regulation by host of viral transcription]
GO:0043923 [positive regulation by host of viral transcription]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
Show all
 485 aa
56.1 kDa 		No 0
ZNF639-004
ENSP00000418870
ENST00000491818
J3KR59 [Direct mapping]
Zinc finger protein 639
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
Show all
 216 aa
24.5 kDa 		No 0
ZNF639-005
ENSP00000418628
ENST00000481587
C9IZP0 [Direct mapping]
Zinc finger protein 639
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 137 aa
15.6 kDa 		No 0
ZNF639-006
ENSP00000419650
ENST00000466264
J3KR68 [Direct mapping]
Zinc finger protein 639
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0046872 [metal ion binding]
Show all
 288 aa
33 kDa 		No 0
ZNF639-007
ENSP00000417232
ENST00000494234
C9J3R1 [Direct mapping]
Zinc finger protein 639
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 130 aa
14.8 kDa 		No 0
ZNF639-201
ENSP00000477626
ENST00000621687
Q9UID6 [Direct mapping]
Zinc finger protein 639
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030307 [positive regulation of cell growth]
GO:0043621 [protein self-association]
GO:0043922 [negative regulation by host of viral transcription]
GO:0043923 [positive regulation by host of viral transcription]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046718 [viral entry into host cell]
GO:0046872 [metal ion binding]
Show all
 485 aa
56.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.