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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PIK3CA
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PIK3CA

Gene description

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA009985 , CAB017804
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA009985
CAB017804

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells showed moderate to strong cytoplasmic immunoreactivity with a granular pattern. Most gliomas and several cases of renal, testicular and breast cancers were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells showed moderate to strong cytoplasmic immunoreactivity.

GENE INFORMATION

Gene name

PIK3CA (HGNC Symbol)

Synonyms

PI3K

Description

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (HGNC Symbol)

Entrez gene summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q26.32

Chromosome location (bp)

179148114 - 179240093

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121879 (version 83.38)

Entrez gene

5290

UniProt

P42336 (UniProt - Evidence at protein level)

neXtProt

NX_P42336

Antibodypedia

PIK3CA antibodies

PROTEIN BROWSER

PIK3CA-001
PIK3CA-002
PIK3CA-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIK3CA-001
ENSP00000263967
ENST00000263967
P42336 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Atypical kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001889 [liver development]
GO:0001944 [vasculature development]
GO:0002250 [adaptive immune response]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0005943 [phosphatidylinositol 3-kinase complex, class IA]
GO:0006006 [glucose metabolic process]
GO:0006468 [protein phosphorylation]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006954 [inflammatory response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016301 [kinase activity]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030027 [lamellipodium]
GO:0030168 [platelet activation]
GO:0030295 [protein kinase activator activity]
GO:0031295 [T cell costimulation]
GO:0032147 [activation of protein kinase activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035004 [phosphatidylinositol 3-kinase activity]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0040014 [regulation of multicellular organism growth]
GO:0043457 [regulation of cellular respiration]
GO:0043491 [protein kinase B signaling]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043542 [endothelial cell migration]
GO:0043560 [insulin receptor substrate binding]
GO:0044029 [hypomethylation of CpG island]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0060048 [cardiac muscle contraction]
GO:0060326 [cell chemotaxis]
GO:0060612 [adipose tissue development]
GO:0071333 [cellular response to glucose stimulus]
GO:0097009 [energy homeostasis]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:2000270 [negative regulation of fibroblast apoptotic process]
GO:2000653 [regulation of genetic imprinting]
GO:2000811 [negative regulation of anoikis]
Show all
1068 aa
124.3 kDa
No 0
PIK3CA-002
ENSP00000418145
ENST00000477735
C9J951 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0060326 [cell chemotaxis]
Show all
21 aa
2.4 kDa
No 0
PIK3CA-003
ENSP00000417479
ENST00000468036
C9JAM9 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0060326 [cell chemotaxis]
Show all
118 aa
13.8 kDa
No 0

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