Expression of CPXM2 in cancer - Summary - The Human Protein Atlas

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CPXM2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CPXM2
Gene description	Carboxypeptidase X (M14 family), member 2
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (BJ)
HPA (normal tissue):	Tissue enhanced (epididymis, smooth muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic/membranous expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA048375
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048375

GENE INFORMATION
Gene name	CPXM2 (HGNC Symbol)
Synonyms	CPX2, UNQ676
Description	Carboxypeptidase X (M14 family), member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q26.13
Chromosome location (bp)	123706207 - 123940267
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121898 (version 83.38)
Entrez gene	119587
UniProt	Q8N436 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N436
Antibodypedia	CPXM2 antibodies

PROTEIN BROWSER

CPXM2-002	CPXM2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPXM2-002 ENSP00000241305 ENST00000241305	Q8N436 [Direct mapping] Inactive carboxypeptidase-like protein X2 Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	756 aa 85.9 kDa	Yes	0
CPXM2-201 ENSP00000483180 ENST00000615851	Q49AT5 [Direct mapping] CPXM2 protein; Inactive carboxypeptidase-like protein X2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004181 [metallocarboxypeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	224 aa 25.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.