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CLCC1

GENERAL INFORMATION

Gene name

 CLCC1

Gene description

 Chloride channel CLIC-like 1

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity supports the protein expression profile.

Reliability score

 Supported based on 2 antibodies.
HPA009087 , HPA013210
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA009087
HPA013210

GENE INFORMATION

Gene name

 CLCC1 (HGNC Symbol)

Synonyms

 MCLC

Description

 Chloride channel CLIC-like 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 108929508 - 108963457

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121940 (version 83.38)

Entrez gene

 23155

UniProt

 Q96S66 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96S66

Antibodypedia

 CLCC1 antibodies

PROTEIN BROWSER
CLCC1-001
CLCC1-002
CLCC1-003
CLCC1-004
CLCC1-005
CLCC1-201
CLCC1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLCC1-001
ENSP00000349456
ENST00000356970
Q96S66 [Direct mapping]
Chloride channel CLIC-like protein 1
A0A024R0G0 [Target identity:100%; Query identity:100%]
Chloride channel CLIC-like 1, isoform CRA_b
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0016020 [membrane]
GO:0034707 [chloride channel complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:1902476 [chloride transmembrane transport]
Show all
 551 aa
62 kDa 		Yes 3
CLCC1-002
ENSP00000358993
ENST00000369976
Q5T1P5 [Direct mapping]
Chloride channel CLIC-like protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0016021 [integral component of membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 262 aa
30.1 kDa 		Yes 2
CLCC1-003
ENSP00000358987
ENST00000369970
Q96S66 [Direct mapping]
Chloride channel CLIC-like protein 1
A0A024R095 [Target identity:100%; Query identity:100%]
Chloride channel CLIC-like 1, isoform CRA_a
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0016020 [membrane]
GO:0034707 [chloride channel complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:1902476 [chloride transmembrane transport]
Show all
 501 aa
56.3 kDa 		Yes 3
CLCC1-004
ENSP00000337243
ENST00000348264
Q96S66 [Direct mapping]
Chloride channel CLIC-like protein 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0016020 [membrane]
GO:0034707 [chloride channel complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:1902476 [chloride transmembrane transport]
Show all
 366 aa
39.8 kDa 		Yes 1
CLCC1-005
ENSP00000306552
ENST00000302500
Q96S66 [Direct mapping]
Chloride channel CLIC-like protein 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0016020 [membrane]
GO:0034707 [chloride channel complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:1902476 [chloride transmembrane transport]
Show all
 430 aa
47.4 kDa 		Yes 1
CLCC1-201
ENSP00000358985
ENST00000369968
Q96S66 [Direct mapping]
Chloride channel CLIC-like protein 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0016020 [membrane]
GO:0034707 [chloride channel complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:1902476 [chloride transmembrane transport]
Show all
 366 aa
39.8 kDa 		Yes 1
CLCC1-202
ENSP00000358986
ENST00000369969
Q96S66 [Direct mapping]
Chloride channel CLIC-like protein 1
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0016020 [membrane]
GO:0034707 [chloride channel complex]
GO:0043231 [intracellular membrane-bounded organelle]
GO:1902476 [chloride transmembrane transport]
Show all
 430 aa
47.4 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.