Tissue expression of POLK - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	POLK
Gene description	Polymerase (DNA directed) kappa
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	POLK (HGNC Symbol)
Synonyms	DINB1, DINP, POLQ
Description	Polymerase (DNA directed) kappa (HGNC Symbol)
Entrez gene summary	External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).[supplied by OMIM, Jan 2010]
Chromosome	5
Cytoband	q13.3
Chromosome location (bp)	75511756 - 75601144
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122008 (version 83.38)
Entrez gene	51426
UniProt	Q9UBT6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBT6
Antibodypedia	POLK antibodies

PROTEIN BROWSER

POLK-001	POLK-002	POLK-004	POLK-007	POLK-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLK-001 ENSP00000241436 ENST00000241436	Q9UBT6 [Direct mapping] DNA polymerase kappa A0A024RAP4 [Target identity:100%; Query identity:100%] Polymerase (DNA directed) kappa, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006297 [nucleotide-excision repair, DNA gap filling] GO:0019985 [translesion synthesis] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0042276 [error-prone translesion synthesis] GO:0046872 [metal ion binding] GO:0070911 [global genome nucleotide-excision repair] Show all	870 aa 98.8 kDa	No	0
POLK-002 ENSP00000425208 ENST00000514296	D6RDX9 [Direct mapping] DNA polymerase kappa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006281 [DNA repair] Show all	141 aa 16.2 kDa	No	0
POLK-004 ENSP00000424174 ENST00000515295	Q9UBT6 [Direct mapping] DNA polymerase kappa Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003684 [damaged DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0005654 [nucleoplasm] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006297 [nucleotide-excision repair, DNA gap filling] GO:0019985 [translesion synthesis] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0042276 [error-prone translesion synthesis] GO:0046872 [metal ion binding] GO:0070911 [global genome nucleotide-excision repair] Show all	472 aa 54.1 kDa	No	0
POLK-007 ENSP00000425075 ENST00000504026	Q9UBT6 [Direct mapping] DNA polymerase kappa Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003684 [damaged DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0005654 [nucleoplasm] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006297 [nucleotide-excision repair, DNA gap filling] GO:0019985 [translesion synthesis] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0042276 [error-prone translesion synthesis] GO:0046872 [metal ion binding] GO:0070911 [global genome nucleotide-excision repair] Show all	461 aa 52.8 kDa	No	0
POLK-011 ENSP00000426853 ENST00000508526	Q9UBT6 [Direct mapping] DNA polymerase kappa Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003684 [damaged DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0005654 [nucleoplasm] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006297 [nucleotide-excision repair, DNA gap filling] GO:0019985 [translesion synthesis] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0042276 [error-prone translesion synthesis] GO:0046872 [metal ion binding] GO:0070911 [global genome nucleotide-excision repair] Show all	672 aa 76.5 kDa	No	0