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RPL21

GENERAL INFORMATION

Gene name

 RPL21

Gene description

 Ribosomal protein L21

Protein class

 Disease related genes
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA047252
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable).
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047252

GENE INFORMATION

Gene name

 RPL21 (HGNC Symbol)

Synonyms

 DKFZp686C06101, FLJ27458, L21, MGC104274, MGC104275, MGC71252

Description

 Ribosomal protein L21 (HGNC Symbol)

Entrez gene summary

 Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

 13

Cytoband

 q12.2

Chromosome location (bp)

 27251309 - 27256691

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122026 (version 83.38)

Entrez gene

 6144

UniProt

 P46778 (UniProt - Evidence at protein level)

neXtProt

 NX_P46778

Antibodypedia

 RPL21 antibodies

PROTEIN BROWSER
RPL21-001
RPL21-003
RPL21-004
RPL21-005
RPL21-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPL21-001
ENSP00000346027
ENST00000311549
P46778 [Direct mapping]
60S ribosomal protein L21
Q6IAX2 [Target identity:100%; Query identity:100%]
RPL21 protein; Ribosomal protein L21; Ribosomal protein L21, isoform CRA_a; cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA
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Ribosomal proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 160 aa
18.6 kDa 		No 0
RPL21-003
ENSP00000351021
ENST00000272274
P46778 [Direct mapping]
60S ribosomal protein L21
Q6IAX2 [Target identity:100%; Query identity:100%]
RPL21 protein; Ribosomal protein L21; Ribosomal protein L21, isoform CRA_a; cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA
Show all
Ribosomal proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 160 aa
18.6 kDa 		No 0
RPL21-004
ENSP00000370574
ENST00000319826
P46778 [Direct mapping]
60S ribosomal protein L21
Q6IAX2 [Target identity:100%; Query identity:100%]
RPL21 protein; Ribosomal protein L21; Ribosomal protein L21, isoform CRA_a; cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA
Show all
Ribosomal proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 160 aa
18.6 kDa 		No 0
RPL21-005
ENSP00000370569
ENST00000326092
P46778 [Direct mapping]
60S ribosomal protein L21
Q6IAX2 [Target identity:100%; Query identity:100%]
RPL21 protein; Ribosomal protein L21; Ribosomal protein L21, isoform CRA_a; cDNA, FLJ92056, Homo sapiens ribosomal protein L21 (RPL21), mRNA
Show all
Ribosomal proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022625 [cytosolic large ribosomal subunit]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 160 aa
18.6 kDa 		No 0
RPL21-009
ENSP00000471695
ENST00000493317
M0R181 [Direct mapping]
60S ribosomal protein L21
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 122 aa
14.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.