Expression of GTF3A in cancer - Summary - The Human Protein Atlas

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GTF3A

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GTF3A
Gene description	General transcription factor IIIA
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA007990
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007990

GENE INFORMATION
Gene name	GTF3A (HGNC Symbol)
Synonyms	AP2, TFIIIA
Description	General transcription factor IIIA (HGNC Symbol)
Entrez gene summary	The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q12.2
Chromosome location (bp)	27424544 - 27435823
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122034 (version 83.38)
Entrez gene	2971
UniProt	Q92664 (UniProt - Evidence at protein level)
neXtProt	NX_Q92664
Antibodypedia	GTF3A antibodies

PROTEIN BROWSER

GTF3A-001	GTF3A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GTF3A-001 ENSP00000370532 ENST00000381140	Q92664 [Direct mapping] Transcription factor IIIA Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0009303 [rRNA transcription] GO:0010467 [gene expression] GO:0046872 [metal ion binding] Show all	365 aa 41.5 kDa	No	0
GTF3A-201 ENSP00000393050 ENST00000439403	B7ZBK4 [Direct mapping] Transcription factor IIIA Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	422 aa 46.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.