Expression of PAEP in cancer - Summary - The Human Protein Atlas

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PAEP

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PAEP
Gene description	Progestagen-associated endometrial protein
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (melanoma)
HPA (cell line):	Cell line enriched (SK-MEL-30)
HPA (normal tissue):	Tissue enriched (endometrium)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in decidual cells and a subset of uterine glands.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA020108 , HPA029473 , CAB016762
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and stomach cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020108	HPA029473	CAB016762

GENE INFORMATION
Gene name	PAEP (HGNC Symbol)
Synonyms	GD, GdA, GdF, GdS, MGC138509, MGC142288, PAEG, PEP, PP14
Description	Progestagen-associated endometrial protein (HGNC Symbol)
Entrez gene summary	This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	135561756 - 135566955
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122133 (version 83.38)
Entrez gene	5047
UniProt	P09466 (UniProt - Evidence at protein level)
neXtProt	NX_P09466
Antibodypedia	PAEP antibodies

PROTEIN BROWSER

PAEP-001	PAEP-002	PAEP-003	PAEP-005	PAEP-006	PAEP-007	PAEP-008	PAEP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAEP-001 ENSP00000417898 ENST00000479141	P09466 [Direct mapping] Glycodelin A0A024R8D8 [Target identity:100%; Query identity:100%] Progestagen-associated endometrial protein (Placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein), isoform CRA_d Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0007275 [multicellular organismal development] GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0036094 [small molecule binding] GO:2000667 [positive regulation of interleukin-13 secretion] GO:2000778 [positive regulation of interleukin-6 secretion] Show all	180 aa 20.6 kDa	Yes	0
PAEP-002 ENSP00000360831 ENST00000371766	P09466 [Direct mapping] Glycodelin A0A024R8D8 [Target identity:100%; Query identity:100%] Progestagen-associated endometrial protein (Placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein), isoform CRA_d Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0007275 [multicellular organismal development] GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0036094 [small molecule binding] GO:2000667 [positive regulation of interleukin-13 secretion] GO:2000778 [positive regulation of interleukin-6 secretion] Show all	180 aa 20.6 kDa	Yes	0
PAEP-003 ENSP00000277508 ENST00000277508	P09466 [Direct mapping] Glycodelin A0A024R8D8 [Target identity:100%; Query identity:100%] Progestagen-associated endometrial protein (Placental protein 14, pregnancy-associated endometrial alpha-2-globulin, alpha uterine protein), isoform CRA_d Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0007275 [multicellular organismal development] GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0036094 [small molecule binding] GO:2000667 [positive regulation of interleukin-13 secretion] GO:2000778 [positive regulation of interleukin-6 secretion] Show all	180 aa 20.6 kDa	Yes	0
PAEP-005 ENSP00000401933 ENST00000418284	Q5T6T6 [Direct mapping] Glycodelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] Show all	132 aa 15.5 kDa	No	0
PAEP-006 ENSP00000396196 ENST00000457014	H0Y530 [Direct mapping] Glycodelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		33 aa 4 kDa	No	0
PAEP-007 ENSP00000394216 ENST00000433563	H0Y4U4 [Direct mapping] Glycodelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] Show all	131 aa 15 kDa	No	0
PAEP-008 ENSP00000404033 ENST00000454923	H0Y6A4 [Direct mapping] Glycodelin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] Show all	126 aa 14.8 kDa	No	0
PAEP-201 ENSP00000484659 ENST00000611414	A6XNE0 [Direct mapping] Glycodelin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006810 [transport] Show all	143 aa 16.4 kDa	Yes	0

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