Expression of OBP2A in cancer - Summary - The Human Protein Atlas

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OBP2A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OBP2A
Gene description	Odorant binding protein 2A
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (ovarian cancer)
HPA (cell line):	Group enriched (U-266/70, U-266/84)
HPA (normal tissue):	Group enriched (fallopian tube, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 1 antibody. HPA055955
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (ovarian cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055955

GENE INFORMATION
Gene name	OBP2A (HGNC Symbol)
Synonyms	hOBPIIa, LCN13, OBP
Description	Odorant binding protein 2A (HGNC Symbol)
Entrez gene summary	This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	135546139 - 135549969
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122136 (version 83.38)
Entrez gene	29991
UniProt	Q9NY56 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NY56
Antibodypedia	OBP2A antibodies

PROTEIN BROWSER

OBP2A-001	OBP2A-002	OBP2A-004	OBP2A-006	OBP2A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OBP2A-001 ENSP00000342097 ENST00000340780	Q5T8A5 [Direct mapping] Odorant-binding protein 2a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		228 aa 26 kDa	Yes	0
OBP2A-002 ENSP00000360841 ENST00000371776	Q9NY56 [Direct mapping] Odorant-binding protein 2a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005549 [odorant binding] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0006810 [transport] GO:0007606 [sensory perception of chemical stimulus] GO:0007608 [sensory perception of smell] GO:0050896 [response to stimulus] Show all	170 aa 19.3 kDa	Yes	0
OBP2A-004 ENSP00000340950 ENST00000342114	Q5T8A4 [Direct mapping] Odorant-binding protein 2a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		147 aa 15.7 kDa	Yes	0
OBP2A-006 ENSP00000441028 ENST00000539850	Q9NY56 [Direct mapping] Odorant-binding protein 2a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005549 [odorant binding] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0006810 [transport] GO:0007606 [sensory perception of chemical stimulus] GO:0007608 [sensory perception of smell] GO:0050896 [response to stimulus] Show all	170 aa 19.3 kDa	Yes	0
OBP2A-201 ENSP00000481115 ENST00000619164	A0A087WXL2 [Direct mapping] Odorant-binding protein 2a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		220 aa 24.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.