Expression of CD244 in cancer - Summary - The Human Protein Atlas

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CD244

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	CD244
Gene description	CD244 molecule, natural killer cell receptor 2B4
Protein class	CD markers Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL, HMC-1, U-937)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	CD244 (HGNC Symbol)
Synonyms	2B4, NAIL, NKR2B4, Nmrk, SLAMF4
Description	CD244 molecule, natural killer cell receptor 2B4 (HGNC Symbol)
Entrez gene summary	This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	160830160 - 160862855
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122223 (version 83.38)
Entrez gene	51744
UniProt	Q9BZW8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZW8
Antibodypedia	CD244 antibodies

PROTEIN BROWSER

CD244-001	CD244-002	CD244-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD244-001 ENSP00000357013 ENST00000368034	Q9BZW8 [Direct mapping] Natural killer cell receptor 2B4 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0050900 [leukocyte migration] Show all	365 aa 41.1 kDa	Yes	1
CD244-002 ENSP00000357012 ENST00000368033	Q9BZW8 [Direct mapping] Natural killer cell receptor 2B4 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0050900 [leukocyte migration] Show all	370 aa 41.6 kDa	Yes	1
CD244-004 ENSP00000313619 ENST00000322302	Q9BZW8 [Direct mapping] Natural killer cell receptor 2B4 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0050900 [leukocyte migration] Show all	273 aa 30.8 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.