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HS3ST2

GENERAL INFORMATION

Gene name

 HS3ST2

Gene description

 Heparan sulfate (glucosamine) 3-O-sulfotransferase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex)
FANTOM5:Tissue enhanced (adipose tissue, lung)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression with a granular pattern in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA017736
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, lung)

GENE INFORMATION

Gene name

 HS3ST2 (HGNC Symbol)

Synonyms

 3OST2

Description

 Heparan sulfate (glucosamine) 3-O-sulfotransferase 2 (HGNC Symbol)

Entrez gene summary

 Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p12.2

Chromosome location (bp)

 22814177 - 22916338

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122254 (version 83.38)

Entrez gene

 9956

UniProt

 Q9Y278 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y278

Antibodypedia

 HS3ST2 antibodies

PROTEIN BROWSER
HS3ST2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HS3ST2-001
ENSP00000261374
ENST00000261374
Q9Y278 [Direct mapping]
Heparan sulfate glucosamine 3-O-sulfotransferase 2
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
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GO:0000139 [Golgi membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0007623 [circadian rhythm]
GO:0008146 [sulfotransferase activity]
GO:0016021 [integral component of membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0033871 [[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity]
GO:0044281 [small molecule metabolic process]
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 367 aa
41.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.