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RBBP6

GENERAL INFORMATION

Gene name

 RBBP6

Gene description

 Retinoblastoma binding protein 6

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Low nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA041725 , CAB032866
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041725
CAB032866

GENE INFORMATION

Gene name

 RBBP6 (HGNC Symbol)

Synonyms

 P2P-R, PACT, SNAMA

Description

 Retinoblastoma binding protein 6 (HGNC Symbol)

Entrez gene summary

 The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p12.1

Chromosome location (bp)

 24537693 - 24572863

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122257 (version 83.38)

Entrez gene

 5930

UniProt

 Q7Z6E9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z6E9

Antibodypedia

 RBBP6 antibodies

PROTEIN BROWSER
RBBP6-001
RBBP6-002
RBBP6-003
RBBP6-005
RBBP6-006
RBBP6-007
RBBP6-009
RBBP6-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBBP6-001
ENSP00000317872
ENST00000319715
Q7Z6E9 [Direct mapping]
E3 ubiquitin-protein ligase RBBP6
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001701 [in utero embryonic development]
GO:0003676 [nucleic acid binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006260 [DNA replication]
GO:0006275 [regulation of DNA replication]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0035264 [multicellular organism growth]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0048568 [embryonic organ development]
GO:0061053 [somite development]
GO:0061630 [ubiquitin protein ligase activity]
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 1792 aa
201.6 kDa 		No 0
RBBP6-002
ENSP00000316291
ENST00000348022
Q7Z6E9 [Direct mapping]
E3 ubiquitin-protein ligase RBBP6
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006260 [DNA replication]
GO:0006275 [regulation of DNA replication]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0061630 [ubiquitin protein ligase activity]
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 1758 aa
197.3 kDa 		No 0
RBBP6-003
ENSP00000390537
ENST00000452655
Q7Z6E9 [Direct mapping]
E3 ubiquitin-protein ligase RBBP6
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006260 [DNA replication]
GO:0006275 [regulation of DNA replication]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0061630 [ubiquitin protein ligase activity]
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 118 aa
13.2 kDa 		No 0
RBBP6-005
ENSP00000370427
ENST00000381039
Q7Z6E9 [Direct mapping]
E3 ubiquitin-protein ligase RBBP6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0006260 [DNA replication]
GO:0006275 [regulation of DNA replication]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008270 [zinc ion binding]
GO:0016874 [ligase activity]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0061630 [ubiquitin protein ligase activity]
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 952 aa
106 kDa 		No 0
RBBP6-006
ENSP00000456750
ENST00000564314
H3BSK8 [Direct mapping]
E3 ubiquitin-protein ligase RBBP6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
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 1008 aa
113.5 kDa 		No 0
RBBP6-007
ENSP00000457716
ENST00000567686
H3BUN0 [Direct mapping]
E3 ubiquitin-protein ligase RBBP6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
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 300 aa
33 kDa 		No 0
RBBP6-009
ENSP00000460821
ENST00000568015
I3L3Y2 [Direct mapping]
E3 ubiquitin-protein ligase RBBP6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
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 158 aa
17.3 kDa 		No 0
RBBP6-010
ENSP00000481477
ENST00000562683
A0A087WY32 [Direct mapping]
E3 ubiquitin-protein ligase RBBP6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0008270 [zinc ion binding]
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 138 aa
15 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.