Expression of LDB3 in cancer - Summary - The Human Protein Atlas

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LDB3

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LDB3
Gene description	LIM domain binding 3
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (SCLC-21H)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in heart and skeletal muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA048955
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048955

GENE INFORMATION
Gene name	LDB3 (HGNC Symbol)
Synonyms	CMD1C, KIAA0613, PDLIM6, ZASP
Description	LIM domain binding 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010]
Chromosome	10
Cytoband	q23.2
Chromosome location (bp)	86668449 - 86736068
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122367 (version 83.38)
Entrez gene	11155
UniProt	O75112 (UniProt - Evidence at protein level)
neXtProt	NX_O75112
Antibodypedia	LDB3 antibodies

PROTEIN BROWSER

LDB3-001	LDB3-002	LDB3-005	LDB3-006	LDB3-007	LDB3-008	LDB3-009	LDB3-201	LDB3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LDB3-001 ENSP00000355296 ENST00000361373	O75112 [Direct mapping] LIM domain-binding protein 3 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0008092 [cytoskeletal protein binding] GO:0008270 [zinc ion binding] GO:0030018 [Z disc] GO:0031143 [pseudopodium] GO:0048471 [perinuclear region of cytoplasm] Show all	727 aa 77.1 kDa	No	0
LDB3-002 ENSP00000361136 ENST00000372066	O75112 [Direct mapping] LIM domain-binding protein 3 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0008092 [cytoskeletal protein binding] GO:0008270 [zinc ion binding] GO:0030018 [Z disc] GO:0031143 [pseudopodium] GO:0048471 [perinuclear region of cytoplasm] Show all	283 aa 31 kDa	No	0
LDB3-005 ENSP00000485538 ENST00000477489	A0A096LPD7 [Direct mapping] LIM domain-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	81 aa 9.2 kDa	No	0
LDB3-006 ENSP00000485389 ENST00000623007	O75112 [Direct mapping] LIM domain-binding protein 3 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0008092 [cytoskeletal protein binding] GO:0008270 [zinc ion binding] GO:0030018 [Z disc] GO:0031143 [pseudopodium] GO:0048471 [perinuclear region of cytoplasm] Show all	330 aa 35.6 kDa	No	0
LDB3-007 ENSP00000361126 ENST00000372056	O75112 [Direct mapping] LIM domain-binding protein 3 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0008092 [cytoskeletal protein binding] GO:0008270 [zinc ion binding] GO:0030018 [Z disc] GO:0031143 [pseudopodium] GO:0048471 [perinuclear region of cytoplasm] Show all	398 aa 42.8 kDa	No	0
LDB3-008 ENSP00000263066 ENST00000263066	O75112 [Direct mapping] LIM domain-binding protein 3 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0008092 [cytoskeletal protein binding] GO:0008270 [zinc ion binding] GO:0030018 [Z disc] GO:0031143 [pseudopodium] GO:0048471 [perinuclear region of cytoplasm] Show all	617 aa 66.7 kDa	No	0
LDB3-009 ENSP00000485500 ENST00000623056	O75112 [Direct mapping] LIM domain-binding protein 3 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0008092 [cytoskeletal protein binding] GO:0008270 [zinc ion binding] GO:0030018 [Z disc] GO:0031143 [pseudopodium] GO:0048471 [perinuclear region of cytoplasm] Show all	732 aa 78.5 kDa	No	0
LDB3-201 ENSP00000401437 ENST00000429277	O75112 [Direct mapping] LIM domain-binding protein 3 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005856 [cytoskeleton] GO:0008092 [cytoskeletal protein binding] GO:0008270 [zinc ion binding] GO:0030018 [Z disc] GO:0031143 [pseudopodium] GO:0045214 [sarcomere organization] GO:0048471 [perinuclear region of cytoplasm] GO:0051371 [muscle alpha-actinin binding] Show all	732 aa 78.5 kDa	No	0
LDB3-202 ENSP00000438866 ENST00000542786	A0A0C4DGG7 [Direct mapping] LIM domain-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	231 aa 24.3 kDa	No	0

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The Human Protein Atlas

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