Cell atlas - PTGFR - The Human Protein Atlas

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PTGFR

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	PTGFR
Gene description	Prostaglandin F receptor (FP)
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	PTGFR (HGNC Symbol)
Synonyms	FP
Description	Prostaglandin F receptor (FP) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p31.1
Chromosome location (bp)	78303884 - 78539749
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122420 (version 83.38)
Entrez gene	5737
UniProt	P43088 (UniProt - Evidence at protein level)
neXtProt	NX_P43088
Antibodypedia	PTGFR antibodies

PROTEIN BROWSER

PTGFR-001	PTGFR-002	PTGFR-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTGFR-001 ENSP00000359793 ENST00000370757	P43088 [Direct mapping] Prostaglandin F2-alpha receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004958 [prostaglandin F receptor activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007567 [parturition] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016021 [integral component of membrane] GO:0032355 [response to estradiol] GO:0032496 [response to lipopolysaccharide] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0043066 [negative regulation of apoptotic process] GO:0071799 [cellular response to prostaglandin D stimulus] Show all	359 aa 40.1 kDa	No	7
PTGFR-002 ENSP00000359794 ENST00000370758	P43088 [Direct mapping] Prostaglandin F2-alpha receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004958 [prostaglandin F receptor activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007567 [parturition] GO:0008284 [positive regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0071799 [cellular response to prostaglandin D stimulus] Show all	359 aa 40.1 kDa	No	7
PTGFR-003 ENSP00000359792 ENST00000370756	P43088 [Direct mapping] Prostaglandin F2-alpha receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004958 [prostaglandin F receptor activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007567 [parturition] GO:0008284 [positive regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0071799 [cellular response to prostaglandin D stimulus] Show all	297 aa 33.7 kDa	No	6

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.