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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

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Score

Score

Score

Antibodies

Column

 
 
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NXPH1
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

NXPH1

Gene description

Neurexophilin 1

Protein class

Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (adrenal gland, cerebral cortex)
GTEx:Tissue enhanced (adrenal gland, hypothalamus)
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland)

Protein evidence

Evidence at transcript level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Uncertain based on 1 antibody.
HPA020062
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
N/A
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland)

GENE INFORMATION

Gene name

NXPH1

Synonyms

Description

Neurexophilin 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the neurexophilin family and encodes a secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p21.3

Chromosome location (bp)

8433955 - 8752963

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000122584 (version 83.38)

Entrez gene

30010

UniProt

P58417 (UniProt - Evidence at transcript level)

neXtProt

NX_P58417

Antibodypedia

NXPH1 antibodies

PROTEIN BROWSER

NXPH1-001
NXPH1-003
NXPH1-004
NXPH1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NXPH1-001
ENSP00000384551
ENST00000405863
P58417 [Direct mapping]
Neurexophilin-1
Q3LID8 [Target identity:100%; Query identity:100%]
Neurexophilin
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005102 [receptor binding]
GO:0005576 [extracellular region]
Show all
271 aa
31.1 kDa
Yes 0
NXPH1-003
ENSP00000404689
ENST00000438764
C9JE46 [Direct mapping]
Neurexophilin-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
139 aa
16 kDa
Yes 0
NXPH1-004
ENSP00000408216
ENST00000429542
C9JPD0 [Direct mapping]
Neurexophilin-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
143 aa
16.5 kDa
Yes 0
NXPH1-201
ENSP00000473269
ENST00000602349
R4GMM9 [Direct mapping]
Neurexophilin
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Show all
253 aa
28.9 kDa
No 0

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