Expression of NT5C3A in cancer - Summary - The Human Protein Atlas

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NT5C3A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NT5C3A
Gene description	5'-nucleotidase, cytosolic IIIA
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA010630 , HPA029058
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010630	HPA029058

GENE INFORMATION
Gene name	NT5C3A (HGNC Symbol)
Synonyms	cN-III, hUMP1, NT5C3, p36, P5'N-1, PN-I, POMP, PSN1, UMPH, UMPH1
Description	5'-nucleotidase, cytosolic IIIA (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012]
Chromosome	7
Cytoband	p14.3
Chromosome location (bp)	33014114 - 33062797
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122643 (version 83.38)
Entrez gene	51251
UniProt	Q9H0P0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H0P0
Antibodypedia	NT5C3A antibodies

PROTEIN BROWSER

NT5C3A-001	NT5C3A-003	NT5C3A-004	NT5C3A-008	NT5C3A-010	NT5C3A-011	NT5C3A-201	NT5C3A-202	NT5C3A-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NT5C3A-001 ENSP00000242210 ENST00000242210	Q9H0P0 [Direct mapping] Cytosolic 5'-nucleotidase 3A Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006213 [pyrimidine nucleoside metabolic process] GO:0008253 [5'-nucleotidase activity] GO:0008665 [2'-phosphotransferase activity] GO:0009117 [nucleotide metabolic process] GO:0016311 [dephosphorylation] GO:0044281 [small molecule metabolic process] GO:0046135 [pyrimidine nucleoside catabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	336 aa 37.9 kDa	Yes	0
NT5C3A-003 ENSP00000387166 ENST00000409467	Q9H0P0 [Direct mapping] Cytosolic 5'-nucleotidase 3A A0A090N7U2 [Target identity:100%; Query identity:100%] 5'-nucleotidase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006213 [pyrimidine nucleoside metabolic process] GO:0008253 [5'-nucleotidase activity] GO:0008665 [2'-phosphotransferase activity] GO:0009117 [nucleotide metabolic process] GO:0016311 [dephosphorylation] GO:0044281 [small molecule metabolic process] GO:0046135 [pyrimidine nucleoside catabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	285 aa 32.6 kDa	No	0
NT5C3A-004 ENSP00000379456 ENST00000396152	Q9H0P0 [Direct mapping] Cytosolic 5'-nucleotidase 3A A0A024RA81 [Target identity:100%; Query identity:100%] 5'-nucleotidase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006213 [pyrimidine nucleoside metabolic process] GO:0008253 [5'-nucleotidase activity] GO:0008665 [2'-phosphotransferase activity] GO:0009117 [nucleotide metabolic process] GO:0016311 [dephosphorylation] GO:0044281 [small molecule metabolic process] GO:0046135 [pyrimidine nucleoside catabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	297 aa 33.9 kDa	No	0
NT5C3A-008 ENSP00000387205 ENST00000409787	B9A035 [Direct mapping] Cytosolic 5'-nucleotidase 3A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005737 [cytoplasm] GO:0008253 [5'-nucleotidase activity] GO:0016311 [dephosphorylation] Show all	205 aa 23.5 kDa	No	0
NT5C3A-010 ENSP00000401161 ENST00000449201	C9K084 [Direct mapping] Cytosolic 5'-nucleotidase 3A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005737 [cytoplasm] GO:0008253 [5'-nucleotidase activity] GO:0016311 [dephosphorylation] Show all	42 aa 4.7 kDa	No	0
NT5C3A-011 ENSP00000476480 ENST00000610140	X6RM59 [Direct mapping] 5'-nucleotidase Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0005737 [cytoplasm] GO:0008253 [5'-nucleotidase activity] GO:0009117 [nucleotide metabolic process] GO:0016311 [dephosphorylation] Show all	331 aa 37.4 kDa	Yes	0
NT5C3A-201 ENSP00000371039 ENST00000381626	Q9H0P0 [Direct mapping] Cytosolic 5'-nucleotidase 3A A0A090N7U2 [Target identity:100%; Query identity:100%] 5'-nucleotidase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006213 [pyrimidine nucleoside metabolic process] GO:0008253 [5'-nucleotidase activity] GO:0008665 [2'-phosphotransferase activity] GO:0009117 [nucleotide metabolic process] GO:0016311 [dephosphorylation] GO:0044281 [small molecule metabolic process] GO:0046135 [pyrimidine nucleoside catabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	285 aa 32.6 kDa	No	0
NT5C3A-202 ENSP00000385261 ENST00000405342	Q9H0P0 [Direct mapping] Cytosolic 5'-nucleotidase 3A A0A024RA81 [Target identity:100%; Query identity:100%] 5'-nucleotidase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006213 [pyrimidine nucleoside metabolic process] GO:0008253 [5'-nucleotidase activity] GO:0008665 [2'-phosphotransferase activity] GO:0009117 [nucleotide metabolic process] GO:0016311 [dephosphorylation] GO:0044281 [small molecule metabolic process] GO:0046135 [pyrimidine nucleoside catabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	297 aa 33.9 kDa	No	0
NT5C3A-203 ENSP00000484415 ENST00000620705	Q9H0P0 [Direct mapping] Cytosolic 5'-nucleotidase 3A Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0006213 [pyrimidine nucleoside metabolic process] GO:0008253 [5'-nucleotidase activity] GO:0008665 [2'-phosphotransferase activity] GO:0009117 [nucleotide metabolic process] GO:0016311 [dephosphorylation] GO:0044281 [small molecule metabolic process] GO:0046085 [adenosine metabolic process] GO:0046135 [pyrimidine nucleoside catabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	336 aa 37.9 kDa	Yes	0

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