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CLTA

GENERAL INFORMATION

Gene name

 CLTA

Gene description

 Clathrin, light chain A

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA050918 , HPA054667 , CAB002665
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), thyroid cancer (favourable) and breast cancer (favourable).
Liver cancer p<0.001
Thyroid cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050918
HPA054667
CAB002665

GENE INFORMATION

Gene name

 CLTA (HGNC Symbol)

Synonyms

 Lca

Description

 Clathrin, light chain A (HGNC Symbol)

Entrez gene summary

 Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]

Chromosome

 9

Cytoband

Chromosome location (bp)

 36190856 - 36304781

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122705 (version 83.38)

Entrez gene

 1211

UniProt

 P09496 (UniProt - Evidence at protein level)

neXtProt

 NX_P09496

Antibodypedia

 CLTA antibodies

PROTEIN BROWSER
CLTA-001
CLTA-002
CLTA-003
CLTA-004
CLTA-005
CLTA-201
CLTA-202
CLTA-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLTA-001
ENSP00000242285
ENST00000242285
P09496 [Direct mapping]
Clathrin light chain A
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005905 [coated pit]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030118 [clathrin coat]
GO:0030125 [clathrin vesicle coat]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
GO:0030136 [clathrin-coated vesicle]
GO:0032050 [clathrin heavy chain binding]
GO:0032588 [trans-Golgi network membrane]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042277 [peptide binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0071439 [clathrin complex]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 248 aa
27.1 kDa 		No 0
CLTA-002
ENSP00000242284
ENST00000345519
P09496 [Direct mapping]
Clathrin light chain A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030118 [clathrin coat]
GO:0030125 [clathrin vesicle coat]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
GO:0032050 [clathrin heavy chain binding]
GO:0032588 [trans-Golgi network membrane]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0071439 [clathrin complex]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 218 aa
23.7 kDa 		No 0
CLTA-003
ENSP00000419746
ENST00000470744
P09496 [Direct mapping]
Clathrin light chain A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030118 [clathrin coat]
GO:0030125 [clathrin vesicle coat]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
GO:0032050 [clathrin heavy chain binding]
GO:0032588 [trans-Golgi network membrane]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0071439 [clathrin complex]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 230 aa
25 kDa 		No 0
CLTA-004
ENSP00000379848
ENST00000396603
P09496 [Direct mapping]
Clathrin light chain A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030118 [clathrin coat]
GO:0030125 [clathrin vesicle coat]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
GO:0032050 [clathrin heavy chain binding]
GO:0032588 [trans-Golgi network membrane]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0071439 [clathrin complex]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 236 aa
25.7 kDa 		No 0
CLTA-005
ENSP00000417698
ENST00000466396
C9J8P9 [Direct mapping]
Clathrin light chain A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030125 [clathrin vesicle coat]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 196 aa
21.1 kDa 		No 0
CLTA-201
ENSP00000401019
ENST00000433436
P09496 [Direct mapping]
Clathrin light chain A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030118 [clathrin coat]
GO:0030125 [clathrin vesicle coat]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
GO:0032050 [clathrin heavy chain binding]
GO:0032588 [trans-Golgi network membrane]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0071439 [clathrin complex]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 248 aa
27.1 kDa 		No 0
CLTA-202
ENSP00000442869
ENST00000538225
P09496 [Direct mapping]
Clathrin light chain A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030118 [clathrin coat]
GO:0030125 [clathrin vesicle coat]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
GO:0032050 [clathrin heavy chain binding]
GO:0032588 [trans-Golgi network membrane]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0071439 [clathrin complex]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 230 aa
25 kDa 		No 0
CLTA-203
ENSP00000437508
ENST00000540080
P09496 [Direct mapping]
Clathrin light chain A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030118 [clathrin coat]
GO:0030125 [clathrin vesicle coat]
GO:0030130 [clathrin coat of trans-Golgi network vesicle]
GO:0030132 [clathrin coat of coated pit]
GO:0032050 [clathrin heavy chain binding]
GO:0032588 [trans-Golgi network membrane]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0071439 [clathrin complex]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 166 aa
17.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.