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NUDT10

GENERAL INFORMATION

Gene name

 NUDT10

Gene description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 10

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, prostate cancer, testis cancer)
HPA (cell line):Group enriched (AF22, HEK93, NTERA-2, SH-SY5Y, U-2 OS)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA047027 , HPA057684
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, prostate cancer, testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047027
HPA057684

GENE INFORMATION

Gene name

 NUDT10 (HGNC Symbol)

Synonyms

 DIPP3a, hDIPP3alpha

Description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 10 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]

Chromosome

 X

Cytoband

 p11.22

Chromosome location (bp)

 51332231 - 51337525

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122824 (version 83.38)

Entrez gene

 170685

UniProt

 Q8NFP7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFP7

Antibodypedia

 NUDT10 antibodies

PROTEIN BROWSER
NUDT10-001
NUDT10-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUDT10-001
ENSP00000348831
ENST00000356450
Q8NFP7 [Direct mapping]
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008486 [diphosphoinositol-polyphosphate diphosphatase activity]
GO:0016787 [hydrolase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0052840 [inositol diphosphate tetrakisphosphate diphosphatase activity]
GO:0052843 [inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052844 [inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052845 [inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity]
GO:0052846 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity]
GO:0052847 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
GO:0052848 [inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
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 164 aa
18.5 kDa 		No 0
NUDT10-002
ENSP00000365174
ENST00000376006
Q8NFP7 [Direct mapping]
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0008486 [diphosphoinositol-polyphosphate diphosphatase activity]
GO:0016787 [hydrolase activity]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0052840 [inositol diphosphate tetrakisphosphate diphosphatase activity]
GO:0052843 [inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052844 [inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity]
GO:0052845 [inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity]
GO:0052846 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity]
GO:0052847 [inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
GO:0052848 [inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity]
Show all
 164 aa
18.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.