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Cytoplasmic expression in several tissues with additional plasma positivity.
DATA RELIABILITY
Data reliability description
Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
P00749 [Direct mapping] Urokinase-type plasminogen activator Urokinase-type plasminogen activator long chain A Urokinase-type plasminogen activator short chain A Urokinase-type plasminogen activator chain B
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Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014)
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GO:0001525 [angiogenesis] GO:0001666 [response to hypoxia] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007283 [spermatogenesis] GO:0007566 [embryo implantation] GO:0007596 [blood coagulation] GO:0008233 [peptidase activity] GO:0008284 [positive regulation of cell proliferation] GO:0009986 [cell surface] GO:0010469 [regulation of receptor activity] GO:0014823 [response to activity] GO:0014909 [smooth muscle cell migration] GO:0014910 [regulation of smooth muscle cell migration] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0031639 [plasminogen activation] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0035728 [response to hepatocyte growth factor] GO:0035729 [cellular response to hepatocyte growth factor stimulus] GO:0042060 [wound healing] GO:0042127 [regulation of cell proliferation] GO:0042730 [fibrinolysis] GO:0043403 [skeletal muscle tissue regeneration] GO:0055093 [response to hyperoxia] GO:0060279 [positive regulation of ovulation] GO:0061041 [regulation of wound healing] GO:0070062 [extracellular exosome] GO:0070997 [neuron death] GO:0071222 [cellular response to lipopolysaccharide] GO:0071310 [cellular response to organic substance] GO:0071333 [cellular response to glucose stimulus] GO:0071456 [cellular response to hypoxia] GO:0071498 [cellular response to fluid shear stress] GO:0072734 [cellular response to staurosporine] GO:2000097 [regulation of smooth muscle cell-matrix adhesion] GO:2000345 [regulation of hepatocyte proliferation] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
