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CHST3

GENERAL INFORMATION

Gene name

 CHST3

Gene description

 Carbohydrate (chondroitin 6) sulfotransferase 3

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA055704
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055704

GENE INFORMATION

Gene name

 CHST3 (HGNC Symbol)

Synonyms

 C6ST, C6ST1

Description

 Carbohydrate (chondroitin 6) sulfotransferase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis. [provided by RefSeq, Mar 2009]

Chromosome

 10

Cytoband

 q22.1

Chromosome location (bp)

 71964365 - 72013564

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122863 (version 83.38)

Entrez gene

 9469

UniProt

 Q7LGC8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7LGC8

Antibodypedia

 CHST3 antibodies

PROTEIN BROWSER
CHST3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHST3-001
ENSP00000362207
ENST00000373115
Q7LGC8 [Direct mapping]
Carbohydrate sulfotransferase 3
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0001517 [N-acetylglucosamine 6-O-sulfotransferase activity]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005975 [carbohydrate metabolic process]
GO:0006790 [sulfur compound metabolic process]
GO:0008146 [sulfotransferase activity]
GO:0008459 [chondroitin 6-sulfotransferase activity]
GO:0014012 [peripheral nervous system axon regeneration]
GO:0016021 [integral component of membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0043029 [T cell homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0050698 [proteoglycan sulfotransferase activity]
GO:0051272 [positive regulation of cellular component movement]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 479 aa
54.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.