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EGR2

GENERAL INFORMATION

Gene name

 EGR2

Gene description

 Early growth response 2

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (U-87 MG)
HPA (normal tissue):Tissue enhanced (epididymis, thyroid gland)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 EGR2 (HGNC Symbol)

Synonyms

 KROX20

Description

 Early growth response 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Chromosome

 10

Cytoband

 q21.3

Chromosome location (bp)

 62811996 - 62919900

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122877 (version 83.38)

Entrez gene

 1959

UniProt

 P11161 (UniProt - Evidence at protein level)

neXtProt

 NX_P11161

Antibodypedia

 EGR2 antibodies

PROTEIN BROWSER
EGR2-001
EGR2-201
EGR2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EGR2-001
ENSP00000242480
ENST00000242480
P11161 [Direct mapping]
E3 SUMO-protein ligase EGR2
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006611 [protein export from nucleus]
GO:0007420 [brain development]
GO:0007422 [peripheral nervous system development]
GO:0007611 [learning or memory]
GO:0007622 [rhythmic behavior]
GO:0008045 [motor neuron axon guidance]
GO:0014037 [Schwann cell differentiation]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0021569 [rhombomere 3 development]
GO:0021612 [facial nerve structural organization]
GO:0021660 [rhombomere 3 formation]
GO:0021666 [rhombomere 5 formation]
GO:0030278 [regulation of ossification]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032868 [response to insulin]
GO:0035284 [brain segmentation]
GO:0035914 [skeletal muscle cell differentiation]
GO:0042552 [myelination]
GO:0043066 [negative regulation of apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045444 [fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0071310 [cellular response to organic substance]
GO:0071320 [cellular response to cAMP]
GO:0071371 [cellular response to gonadotropin stimulus]
GO:0071837 [HMG box domain binding]
Show all
 476 aa
50.3 kDa 		No 0
EGR2-201
ENSP00000387634
ENST00000411732
P11161 [Direct mapping]
E3 SUMO-protein ligase EGR2
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006611 [protein export from nucleus]
GO:0007420 [brain development]
GO:0007422 [peripheral nervous system development]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035914 [skeletal muscle cell differentiation]
GO:0042552 [myelination]
GO:0043066 [negative regulation of apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045444 [fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0071320 [cellular response to cAMP]
GO:0071371 [cellular response to gonadotropin stimulus]
Show all
 426 aa
45 kDa 		No 0
EGR2-202
ENSP00000402040
ENST00000439032
P11161 [Direct mapping]
E3 SUMO-protein ligase EGR2
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006611 [protein export from nucleus]
GO:0007420 [brain development]
GO:0007422 [peripheral nervous system development]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035914 [skeletal muscle cell differentiation]
GO:0042552 [myelination]
GO:0043066 [negative regulation of apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045444 [fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048168 [regulation of neuronal synaptic plasticity]
GO:0071320 [cellular response to cAMP]
GO:0071371 [cellular response to gonadotropin stimulus]
Show all
 476 aa
50.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.