Expression of CIT in cancer - Summary - The Human Protein Atlas

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CIT

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CIT
Gene description	Citron rho-interacting serine/threonine kinase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA019082 , HPA048812
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019082	HPA048812

GENE INFORMATION
Gene name	CIT (HGNC Symbol)
Synonyms	CRIK, KIAA0949, STK21
Description	Citron rho-interacting serine/threonine kinase (HGNC Symbol)
Entrez gene summary	This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Chromosome	12
Cytoband	q24.23
Chromosome location (bp)	119685790 - 119877291
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122966 (version 83.38)
Entrez gene	11113
UniProt	O14578 (UniProt - Evidence at protein level)
neXtProt	NX_O14578
Antibodypedia	CIT antibodies

PROTEIN BROWSER

CIT-001	CIT-005	CIT-006	CIT-008	CIT-011	CIT-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CIT-001 ENSP00000261833 ENST00000261833	O14578 [Direct mapping] Citron Rho-interacting kinase Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000910 [cytokinesis] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0017124 [SH3 domain binding] GO:0030165 [PDZ domain binding] GO:0032467 [positive regulation of cytokinesis] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] GO:0048699 [generation of neurons] GO:0097110 [scaffold protein binding] Show all	2027 aa 231.4 kDa	No	0
CIT-005 ENSP00000376306 ENST00000392521	O14578 [Direct mapping] Citron Rho-interacting kinase Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000070 [mitotic sister chromatid segregation] GO:0000910 [cytokinesis] GO:0001726 [ruffle] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005773 [vacuole] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007067 [mitotic nuclear division] GO:0007091 [metaphase/anaphase transition of mitotic cell cycle] GO:0007264 [small GTPase mediated signal transduction] GO:0007283 [spermatogenesis] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016358 [dendrite development] GO:0017124 [SH3 domain binding] GO:0030165 [PDZ domain binding] GO:0032467 [positive regulation of cytokinesis] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] GO:0048699 [generation of neurons] GO:0050774 [negative regulation of dendrite morphogenesis] GO:0097110 [scaffold protein binding] Show all	2069 aa 236.6 kDa	No	0
CIT-006 ENSP00000376305 ENST00000392520	H7BYJ3 [Direct mapping] Citron Rho-interacting kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] Show all	1640 aa 187.3 kDa	No	0
CIT-008 ENSP00000443199 ENST00000536325	H0YGG8 [Direct mapping] Citron Rho-interacting kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	109 aa 12.6 kDa	No	0
CIT-011 ENSP00000446105 ENST00000546026	F5H4K4 [Direct mapping] Citron Rho-interacting kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		162 aa 18.8 kDa	No	0
CIT-201 ENSP00000482318 ENST00000612548	O14578 [Direct mapping] Citron Rho-interacting kinase Show all	Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000910 [cytokinesis] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0017124 [SH3 domain binding] GO:0030165 [PDZ domain binding] GO:0032467 [positive regulation of cytokinesis] GO:0046872 [metal ion binding] GO:0048699 [generation of neurons] GO:0097110 [scaffold protein binding] Show all	482 aa 54.4 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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