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DDX54

GENERAL INFORMATION

Gene name

 DDX54

Gene description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA028244
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DDX54 (HGNC Symbol)

Synonyms

 APR-5, DP97, MGC2835

Description

 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.13

Chromosome location (bp)

 113157174 - 113185479

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123064 (version 83.38)

Entrez gene

 79039

UniProt

 Q8TDD1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDD1

Antibodypedia

 DDX54 antibodies

PROTEIN BROWSER
DDX54-001
DDX54-002
DDX54-010
DDX54-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX54-001
ENSP00000323858
ENST00000314045
Q8TDD1 [Direct mapping]
ATP-dependent RNA helicase DDX54
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0003723 [RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0016070 [RNA metabolic process]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030331 [estrogen receptor binding]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0044822 [poly(A) RNA binding]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 882 aa
98.7 kDa 		No 0
DDX54-002
ENSP00000304072
ENST00000306014
Q8TDD1 [Direct mapping]
ATP-dependent RNA helicase DDX54
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0003723 [RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006396 [RNA processing]
GO:0010501 [RNA secondary structure unwinding]
GO:0016020 [membrane]
GO:0016070 [RNA metabolic process]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030331 [estrogen receptor binding]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0044822 [poly(A) RNA binding]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 881 aa
98.6 kDa 		No 0
DDX54-010
ENSP00000448477
ENST00000552375
F8VRX4 [Direct mapping]
ATP-dependent RNA helicase DDX54
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0010501 [RNA secondary structure unwinding]
Show all
 208 aa
22.9 kDa 		No 0
DDX54-011
ENSP00000447098
ENST00000546898
H0YHH7 [Direct mapping]
ATP-dependent RNA helicase DDX54
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0010501 [RNA secondary structure unwinding]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
Show all
 160 aa
18.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.