Expression of MED13L in cancer - Summary - The Human Protein Atlas

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MED13L

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MED13L
Gene description	Mediator complex subunit 13-like
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expressed in the cytoplasm in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA039445
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039445

GENE INFORMATION
Gene name	MED13L (HGNC Symbol)
Synonyms	KIAA1025, THRAP2, TRAP240L
Description	Mediator complex subunit 13-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010]
Chromosome	12
Cytoband	q24.21
Chromosome location (bp)	115953872 - 116277338
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123066 (version 83.38)
Entrez gene	23389
UniProt	Q71F56 (UniProt - Evidence at protein level)
neXtProt	NX_Q71F56
Antibodypedia	MED13L antibodies

PROTEIN BROWSER

MED13L-001	MED13L-003	MED13L-005	MED13L-006	MED13L-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MED13L-001 ENSP00000281928 ENST00000281928	Q71F56 [Direct mapping] Mediator of RNA polymerase II transcription subunit 13-like Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	2210 aa 242.6 kDa	No	0
MED13L-003 ENSP00000448553 ENST00000548743	F8VRB8 [Direct mapping] Mediator of RNA polymerase II transcription subunit 13-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		93 aa 10.8 kDa	No	0
MED13L-005 ENSP00000446782 ENST00000549786	H0YHC1 [Direct mapping] Mediator of RNA polymerase II transcription subunit 13-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	190 aa 19.3 kDa	No	0
MED13L-006 ENSP00000449876 ENST00000552340	H0YIQ7 [Direct mapping] Mediator of RNA polymerase II transcription subunit 13-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	140 aa 16 kDa	No	0
MED13L-009 ENSP00000449895 ENST00000552447	H0YIQ9 [Direct mapping] Mediator of RNA polymerase II transcription subunit 13-like Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	195 aa 21.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.