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CDKN2C

GENERAL INFORMATION

Gene name

 CDKN2C

Gene description

 Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 4 antibodies.
HPA019057 , HPA019764 , CAB005303 , CAB018398
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019057
HPA019764
CAB005303
CAB018398

GENE INFORMATION

Gene name

 CDKN2C (HGNC Symbol)

Synonyms

 INK4C, p18

Description

 Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p32.3

Chromosome location (bp)

 50960745 - 50974633

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123080 (version 83.38)

Entrez gene

 1031

UniProt

 P42773 (UniProt - Evidence at protein level)

neXtProt

 NX_P42773

Antibodypedia

 CDKN2C antibodies

PROTEIN BROWSER
CDKN2C-001
CDKN2C-002
CDKN2C-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDKN2C-001
ENSP00000262662
ENST00000262662
P42773 [Direct mapping]
Cyclin-dependent kinase 4 inhibitor C
Q6ICV4 [Target identity:100%; Query identity:100%]
CDKN2C protein; Cyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4), isoform CRA_a; cDNA FLJ33851 fis, clone CTONG2005635, highly similar to CYCLIN-DEPENDENT KINASE 6 INHIBITOR
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007050 [cell cycle arrest]
GO:0008285 [negative regulation of cell proliferation]
GO:0019901 [protein kinase binding]
GO:0030308 [negative regulation of cell growth]
GO:0042326 [negative regulation of phosphorylation]
GO:0048709 [oligodendrocyte differentiation]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Show all
 168 aa
18.1 kDa 		No 0
CDKN2C-002
ENSP00000360826
ENST00000371761
P42773 [Direct mapping]
Cyclin-dependent kinase 4 inhibitor C
Q6ICV4 [Target identity:100%; Query identity:100%]
CDKN2C protein; Cyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4), isoform CRA_a; cDNA FLJ33851 fis, clone CTONG2005635, highly similar to CYCLIN-DEPENDENT KINASE 6 INHIBITOR
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007050 [cell cycle arrest]
GO:0008285 [negative regulation of cell proliferation]
GO:0019901 [protein kinase binding]
GO:0030308 [negative regulation of cell growth]
GO:0042326 [negative regulation of phosphorylation]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Show all
 168 aa
18.1 kDa 		No 0
CDKN2C-201
ENSP00000379452
ENST00000396148
P42773 [Direct mapping]
Cyclin-dependent kinase 4 inhibitor C
Q6ICV4 [Target identity:100%; Query identity:100%]
CDKN2C protein; Cyclin-dependent kinase inhibitor 2C (P18, inhibits CDK4), isoform CRA_a; cDNA FLJ33851 fis, clone CTONG2005635, highly similar to CYCLIN-DEPENDENT KINASE 6 INHIBITOR
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Large Deletions
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007050 [cell cycle arrest]
GO:0008285 [negative regulation of cell proliferation]
GO:0019901 [protein kinase binding]
GO:0030308 [negative regulation of cell growth]
GO:0042326 [negative regulation of phosphorylation]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Show all
 168 aa
18.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.