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WWP1

GENERAL INFORMATION

Gene name

 WWP1

Gene description

 WW domain containing E3 ubiquitin protein ligase 1

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA023180
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023180

GENE INFORMATION

Gene name

 WWP1 (HGNC Symbol)

Synonyms

 AIP5, DKFZP434D2111

Description

 WW domain containing E3 ubiquitin protein ligase 1 (HGNC Symbol)

Entrez gene summary

 WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q21.3

Chromosome location (bp)

 86342738 - 86478420

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123124 (version 83.38)

Entrez gene

 11059

UniProt

 Q9H0M0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H0M0

Antibodypedia

 WWP1 antibodies

PROTEIN BROWSER
WWP1-001
WWP1-006
WWP1-010
WWP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WWP1-001
ENSP00000427793
ENST00000517970
Q9H0M0 [Direct mapping]
NEDD4-like E3 ubiquitin-protein ligase WWP1
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007417 [central nervous system development]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0034220 [ion transmembrane transport]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0055085 [transmembrane transport]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
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 922 aa
105.2 kDa 		No 0
WWP1-006
ENSP00000429076
ENST00000520453
H0YBA4 [Direct mapping]
NEDD4-like E3 ubiquitin-protein ligase WWP1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
Show all
 233 aa
27.1 kDa 		No 1
WWP1-010
ENSP00000430228
ENST00000520798
H0YBS9 [Direct mapping]
NEDD4-like E3 ubiquitin-protein ligase WWP1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
Show all
 55 aa
6.2 kDa 		No 0
WWP1-201
ENSP00000265428
ENST00000265428
Q9H0M0 [Direct mapping]
NEDD4-like E3 ubiquitin-protein ligase WWP1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007417 [central nervous system development]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0034220 [ion transmembrane transport]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046718 [viral entry into host cell]
GO:0055085 [transmembrane transport]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
Show all
 922 aa
105.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.