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PRDX4

GENERAL INFORMATION

Gene name

 PRDX4

Gene description

 Peroxiredoxin 4

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Group enriched (liver, pancreas)

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
CAB008659 , CAB027389
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, pancreas)

GENE INFORMATION

Gene name

 PRDX4 (HGNC Symbol)

Synonyms

 AOE37-2

Description

 Peroxiredoxin 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.11

Chromosome location (bp)

 23664262 - 23686399

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123131 (version 83.38)

Entrez gene

 10549

UniProt

 Q13162 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13162

Antibodypedia

 PRDX4 antibodies

PROTEIN BROWSER
PRDX4-001
PRDX4-002
PRDX4-004
PRDX4-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRDX4-001
ENSP00000368646
ENST00000379341
Q13162 [Direct mapping]
Peroxiredoxin-4
V9HW63 [Target identity:100%; Query identity:100%]
Epididymis secretory sperm binding protein Li 97n; Peroxiredoxin 4
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0007252 [I-kappaB phosphorylation]
GO:0007283 [spermatogenesis]
GO:0008379 [thioredoxin peroxidase activity]
GO:0008584 [male gonad development]
GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0019471 [4-hydroxyproline metabolic process]
GO:0022417 [protein maturation by protein folding]
GO:0030198 [extracellular matrix organization]
GO:0042803 [protein homodimerization activity]
GO:0045454 [cell redox homeostasis]
GO:0051920 [peroxiredoxin activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0072593 [reactive oxygen species metabolic process]
GO:2000255 [negative regulation of male germ cell proliferation]
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 271 aa
30.5 kDa 		Yes 0
PRDX4-002
ENSP00000368654
ENST00000379349
A6NJJ0 [Direct mapping]
Peroxiredoxin-4
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   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 185 aa
21.3 kDa 		No 0
PRDX4-004
ENSP00000368635
ENST00000379331
A6NG45 [Direct mapping]
Peroxiredoxin-4
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 186 aa
21.3 kDa 		Yes 0
PRDX4-005
ENSP00000413736
ENST00000439422
H7C3T4 [Direct mapping]
Peroxiredoxin-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016209 [antioxidant activity]
GO:0016491 [oxidoreductase activity]
GO:0051920 [peroxiredoxin activity]
GO:0055114 [oxidation-reduction process]
Show all
 161 aa
18.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.