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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADGRE5
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADGRE5

Gene description

Adhesion G protein-coupled receptor E5

Protein class

CD markers
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High cytoplasmic expression in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 1 antibody.
HPA013707
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA013707

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignant cells showed weak to moderate cytoplasmic staining. Malignant lymphomas, colorectal and a few ovarian cancers displayed strong cytoplasmic positivity. Testicular, renal, urothelial and hepatocellular carcinomas were negative in a majority of samples.

GENE INFORMATION

Gene name

ADGRE5 (HGNC Symbol)

Synonyms

CD97, TM7LN1

Description

Adhesion G protein-coupled receptor E5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]

Chromosome

19

Cytoband

p13.12

Chromosome location (bp)

14380501 - 14408725

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123146 (version 83.38)

Entrez gene

976

UniProt

P48960 (UniProt - Evidence at protein level)

neXtProt

NX_P48960

Antibodypedia

ADGRE5 antibodies

PROTEIN BROWSER

ADGRE5-001
ADGRE5-002
ADGRE5-003
ADGRE5-006
ADGRE5-008
ADGRE5-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADGRE5-001
ENSP00000351413
ENST00000358600
P48960 [Direct mapping]
CD97 antigen CD97 antigen subunit alpha CD97 antigen subunit beta
Show all
CD markers
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0070062 [extracellular exosome]
Show all
742 aa
81.7 kDa
Yes 7
ADGRE5-002
ENSP00000349918
ENST00000357355
P48960 [Direct mapping]
CD97 antigen CD97 antigen subunit alpha CD97 antigen subunit beta
Show all
CD markers
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0070062 [extracellular exosome]
Show all
786 aa
86.6 kDa
Yes 7
ADGRE5-003
ENSP00000242786
ENST00000242786
P48960 [Direct mapping]
CD97 antigen CD97 antigen subunit alpha CD97 antigen subunit beta
Show all
CD markers
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007155 [cell adhesion]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0070062 [extracellular exosome]
Show all
835 aa
91.9 kDa
Yes 7
ADGRE5-006
ENSP00000465800
ENST00000587606
K7EKV5 [Direct mapping]
Protein ADGRE5
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
Show all
154 aa
16.6 kDa
Yes 0
ADGRE5-008
ENSP00000467351
ENST00000586517
K7EPE8 [Direct mapping]
Protein ADGRE5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
Show all
157 aa
17.1 kDa
No 0
ADGRE5-010
ENSP00000467478
ENST00000592261
K7EPP8 [Direct mapping]
Protein ADGRE5
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
Show all
164 aa
17.6 kDa
Yes 0

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