A majority of malignant cells showed weak to moderate cytoplasmic staining. Malignant lymphomas, colorectal and a few ovarian cancers displayed strong cytoplasmic positivity. Testicular, renal, urothelial and hepatocellular carcinomas were negative in a majority of samples.
ADGRE5 (HGNC Symbol)
Adhesion G protein-coupled receptor E5 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]