Expression of SPRYD7 in cancer - Summary - The Human Protein Atlas

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SPRYD7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPRYD7
Gene description	SPRY domain containing 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043934
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043934

GENE INFORMATION
Gene name	SPRYD7 (HGNC Symbol)
Synonyms	C13orf1, CLLD6
Description	SPRY domain containing 7 (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q14.2
Chromosome location (bp)	49912706 - 49936490
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123178 (version 83.38)
Entrez gene	57213
UniProt	Q5W111 (UniProt - Evidence at protein level)
neXtProt	NX_Q5W111
Antibodypedia	SPRYD7 antibodies

PROTEIN BROWSER

SPRYD7-001	SPRYD7-201	SPRYD7-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPRYD7-001 ENSP00000354774 ENST00000361840	Q5W111 [Direct mapping] SPRY domain-containing protein 7 A0A024RDT6 [Target identity:100%; Query identity:100%] Chromosome 13 open reading frame 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	196 aa 21.7 kDa	No	0
SPRYD7-201 ENSP00000367437 ENST00000378195	Q5W111 [Direct mapping] SPRY domain-containing protein 7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	157 aa 17.5 kDa	No	0
SPRYD7-202 ENSP00000484495 ENST00000613924	Q5W111 [Direct mapping] SPRY domain-containing protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	157 aa 17.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.