Cell atlas - ATP7B - The Human Protein Atlas

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ATP7B

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	ATP7B
Gene description	ATPase, Cu++ transporting, beta polypeptide
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (HEL, BEWO, RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA009137
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, BEWO, RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA009137	CACO-2	Golgi apparatus	Intensity
	HPA009137	Hep G2	Golgi apparatus
	HPA009137	U-2 OS	No staining

GENE INFORMATION
Gene name	ATP7B (HGNC Symbol)
Synonyms	WND
Description	ATPase, Cu++ transporting, beta polypeptide (HGNC Symbol)
Entrez gene summary	This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q14.3
Chromosome location (bp)	51930436 - 52012125
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123191 (version 83.38)
Entrez gene	540
UniProt	P35670 (UniProt - Evidence at protein level)
neXtProt	NX_P35670
Antibodypedia	ATP7B antibodies

PROTEIN BROWSER

ATP7B-002	ATP7B-003	ATP7B-007	ATP7B-008	ATP7B-009	ATP7B-201	ATP7B-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP7B-002 ENSP00000242839 ENST00000242839	P35670 [Direct mapping] Copper-transporting ATPase 2 WND/140 kDa A0A024RDX3 [Target identity:100%; Query identity:100%] ATPase, Cu++ transporting, beta polypeptide, isoform CRA_c Show all	Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000166 [nucleotide binding] GO:0004008 [copper-exporting ATPase activity] GO:0005375 [copper ion transmembrane transporter activity] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005923 [bicellular tight junction] GO:0006812 [cation transport] GO:0006825 [copper ion transport] GO:0006878 [cellular copper ion homeostasis] GO:0006882 [cellular zinc ion homeostasis] GO:0007595 [lactation] GO:0007623 [circadian rhythm] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] GO:0010043 [response to zinc ion] GO:0015677 [copper ion import] GO:0015680 [intracellular copper ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016323 [basolateral plasma membrane] GO:0019829 [cation-transporting ATPase activity] GO:0030001 [metal ion transport] GO:0034220 [ion transmembrane transport] GO:0035434 [copper ion transmembrane transport] GO:0043682 [copper-transporting ATPase activity] GO:0046688 [response to copper ion] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051208 [sequestering of calcium ion] GO:0051591 [response to cAMP] GO:0055085 [transmembrane transport] GO:0060003 [copper ion export] Show all	1465 aa 157.3 kDa	No	8
ATP7B-003 ENSP00000342559 ENST00000344297	P35670 [Direct mapping] Copper-transporting ATPase 2 WND/140 kDa Show all	Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000166 [nucleotide binding] GO:0004008 [copper-exporting ATPase activity] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005887 [integral component of plasma membrane] GO:0006812 [cation transport] GO:0006825 [copper ion transport] GO:0006878 [cellular copper ion homeostasis] GO:0008152 [metabolic process] GO:0015677 [copper ion import] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016323 [basolateral plasma membrane] GO:0019829 [cation-transporting ATPase activity] GO:0030001 [metal ion transport] GO:0034220 [ion transmembrane transport] GO:0046688 [response to copper ion] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051208 [sequestering of calcium ion] GO:0055085 [transmembrane transport] GO:0060003 [copper ion export] Show all	1258 aa 133.6 kDa	No	5
ATP7B-007 ENSP00000383221 ENST00000400370	F5H562 [Direct mapping] Copper-transporting ATPase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005507 [copper ion binding] GO:0006812 [cation transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0019829 [cation-transporting ATPase activity] GO:0030001 [metal ion transport] GO:0046872 [metal ion binding] GO:0098655 [cation transmembrane transport] Show all	1035 aa 110.3 kDa	No	4
ATP7B-008 ENSP00000489398 ENST00000634844	B7ZLR4 [Target identity:100%; Query identity:100%] ATP7B protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005507 [copper ion binding] GO:0006812 [cation transport] GO:0016021 [integral component of membrane] GO:0019829 [cation-transporting ATPase activity] GO:0030001 [metal ion transport] GO:0046872 [metal ion binding] Show all	1417 aa 151.9 kDa	No	7
ATP7B-009 ENSP00000393343 ENST00000418097	F5H748 [Direct mapping] Copper-transporting ATPase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005507 [copper ion binding] GO:0005524 [ATP binding] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0030001 [metal ion transport] GO:0046872 [metal ion binding] Show all	1400 aa 150.5 kDa	No	7
ATP7B-201 ENSP00000383217 ENST00000400366	P35670 [Direct mapping] Copper-transporting ATPase 2 WND/140 kDa Show all	Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0000166 [nucleotide binding] GO:0004008 [copper-exporting ATPase activity] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005887 [integral component of plasma membrane] GO:0006812 [cation transport] GO:0006825 [copper ion transport] GO:0006878 [cellular copper ion homeostasis] GO:0008152 [metabolic process] GO:0015677 [copper ion import] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016323 [basolateral plasma membrane] GO:0019829 [cation-transporting ATPase activity] GO:0030001 [metal ion transport] GO:0034220 [ion transmembrane transport] GO:0046688 [response to copper ion] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051208 [sequestering of calcium ion] GO:0055085 [transmembrane transport] GO:0060003 [copper ion export] Show all	1354 aa 145.8 kDa	No	9
ATP7B-202 ENSP00000416738 ENST00000448424	E7ET55 [Direct mapping] Copper-transporting ATPase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005507 [copper ion binding] GO:0006812 [cation transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0019829 [cation-transporting ATPase activity] GO:0030001 [metal ion transport] GO:0046872 [metal ion binding] GO:0098655 [cation transmembrane transport] Show all	1387 aa 148.4 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.