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TSFM

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GENERAL INFORMATION

Gene name

 TSFM

Gene description

 Ts translation elongation factor, mitochondrial

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria. In addition localized to the nucleus.

RNA cell category

 Cell line enriched (RH-30)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

Additional location

 In addition localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA006204
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (RH-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the mitochondria. In addition localized to the nucleus.

Main location

 Mitochondria (supported)

Additional location

 Nucleus (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA006204 A-431 Nucleoplasm
Mitochondria
HPA006204 U-2 OS Nucleus
Mitochondria
HPA006204 U-251 MG Nucleus
Mitochondria

GENE INFORMATION

Gene name

 TSFM (HGNC Symbol)

Synonyms

 EF-TS, EF-Tsmt

Description

 Ts translation elongation factor, mitochondrial (HGNC Symbol)

Entrez gene summary

 This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

Chromosome

 12

Cytoband

 q14.1

Chromosome location (bp)

 57782589 - 57808071

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123297 (version 83.38)

Entrez gene

 10102

UniProt

 P43897 (UniProt - Evidence at protein level)

neXtProt

 NX_P43897

Antibodypedia

 TSFM antibodies

PROTEIN BROWSER
TSFM-001
TSFM-002
TSFM-005
TSFM-006
TSFM-008
TSFM-009
TSFM-010
TSFM-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TSFM-001
ENSP00000388330
ENST00000454289
P43897 [Direct mapping]
Elongation factor Ts, mitochondrial
E5KS95 [Target identity:100%; Query identity:100%]
Elongation factor Ts, mitochondrial
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006414 [translational elongation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0032784 [regulation of DNA-templated transcription, elongation]
GO:0044822 [poly(A) RNA binding]
GO:0070125 [mitochondrial translational elongation]
Show all
 325 aa
35.4 kDa 		No 0
TSFM-002
ENSP00000313877
ENST00000323833
P43897 [Direct mapping]
Elongation factor Ts, mitochondrial
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006414 [translational elongation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0032784 [regulation of DNA-templated transcription, elongation]
GO:0044822 [poly(A) RNA binding]
GO:0070125 [mitochondrial translational elongation]
Show all
 346 aa
37.7 kDa 		No 0
TSFM-005
ENSP00000390679
ENST00000434359
C9JG32 [Direct mapping]
Elongation factor Ts
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005759 [mitochondrial matrix]
GO:0006414 [translational elongation]
GO:0070125 [mitochondrial translational elongation]
Show all
 140 aa
15.4 kDa 		No 0
TSFM-006
ENSP00000389162
ENST00000457189
C9JT21 [Direct mapping]
Elongation factor Ts
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005759 [mitochondrial matrix]
GO:0006414 [translational elongation]
GO:0070125 [mitochondrial translational elongation]
Show all
 169 aa
18.6 kDa 		No 0
TSFM-008
ENSP00000448575
ENST00000550559
F8VS27 [Direct mapping]
Elongation factor Ts, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005759 [mitochondrial matrix]
GO:0006414 [translational elongation]
GO:0070125 [mitochondrial translational elongation]
Show all
 230 aa
25.1 kDa 		No 0
TSFM-009
ENSP00000450041
ENST00000548851
F8VPA7 [Direct mapping]
Elongation factor Ts, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005759 [mitochondrial matrix]
GO:0006414 [translational elongation]
GO:0070125 [mitochondrial translational elongation]
Show all
 200 aa
22.1 kDa 		No 0
TSFM-010
ENSP00000440987
ENST00000540550
P43897 [Direct mapping]
Elongation factor Ts, mitochondrial
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006414 [translational elongation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0032784 [regulation of DNA-templated transcription, elongation]
GO:0044822 [poly(A) RNA binding]
GO:0070125 [mitochondrial translational elongation]
Show all
 167 aa
18.7 kDa 		No 0
TSFM-201
ENSP00000439342
ENST00000543727
P43897 [Direct mapping]
Elongation factor Ts, mitochondrial
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006414 [translational elongation]
GO:0006996 [organelle organization]
GO:0032543 [mitochondrial translation]
GO:0032784 [regulation of DNA-templated transcription, elongation]
GO:0044822 [poly(A) RNA binding]
GO:0070125 [mitochondrial translational elongation]
Show all
 215 aa
23.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.