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NCKAP1L

GENERAL INFORMATION

Gene name

 NCKAP1L

Gene description

 NCK-associated protein 1-like

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HL-60, HMC-1, THP-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues. Most abundant expression in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA039490 , HPA040772
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA039490
HPA040772

GENE INFORMATION

Gene name

 NCKAP1L (HGNC Symbol)

Synonyms

 HEM1

Description

 NCK-associated protein 1-like (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

Chromosome

 12

Cytoband

Chromosome location (bp)

 54497711 - 54548238

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123338 (version 83.38)

Entrez gene

 3071

UniProt

 P55160 (UniProt - Evidence at protein level)

neXtProt

 NX_P55160

Antibodypedia

 NCKAP1L antibodies

PROTEIN BROWSER
NCKAP1L-001
NCKAP1L-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NCKAP1L-001
ENSP00000293373
ENST00000293373
P55160 [Direct mapping]
Nck-associated protein 1-like
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001782 [B cell homeostasis]
GO:0002262 [myeloid cell homeostasis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006935 [chemotaxis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0030011 [maintenance of cell polarity]
GO:0030295 [protein kinase activator activity]
GO:0030593 [neutrophil chemotaxis]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031209 [SCAR complex]
GO:0032147 [activation of protein kinase activity]
GO:0032403 [protein complex binding]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035509 [negative regulation of myosin-light-chain-phosphatase activity]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042327 [positive regulation of phosphorylation]
GO:0042493 [response to drug]
GO:0043029 [T cell homeostasis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043372 [positive regulation of CD4-positive, alpha-beta T cell differentiation]
GO:0043378 [positive regulation of CD8-positive, alpha-beta T cell differentiation]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045588 [positive regulation of gamma-delta T cell differentiation]
GO:0045621 [positive regulation of lymphocyte differentiation]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048821 [erythrocyte development]
GO:0050853 [B cell receptor signaling pathway]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0070062 [extracellular exosome]
GO:0070358 [actin polymerization-dependent cell motility]
GO:0090023 [positive regulation of neutrophil chemotaxis]
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 1127 aa
128.2 kDa 		No 2
NCKAP1L-002
ENSP00000445596
ENST00000545638
P55160 [Direct mapping]
Nck-associated protein 1-like
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001782 [B cell homeostasis]
GO:0002262 [myeloid cell homeostasis]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006935 [chemotaxis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
GO:0030011 [maintenance of cell polarity]
GO:0030295 [protein kinase activator activity]
GO:0030593 [neutrophil chemotaxis]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0030890 [positive regulation of B cell proliferation]
GO:0031209 [SCAR complex]
GO:0032147 [activation of protein kinase activity]
GO:0032403 [protein complex binding]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035509 [negative regulation of myosin-light-chain-phosphatase activity]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042327 [positive regulation of phosphorylation]
GO:0042493 [response to drug]
GO:0043029 [T cell homeostasis]
GO:0043066 [negative regulation of apoptotic process]
GO:0043372 [positive regulation of CD4-positive, alpha-beta T cell differentiation]
GO:0043378 [positive regulation of CD8-positive, alpha-beta T cell differentiation]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045588 [positive regulation of gamma-delta T cell differentiation]
GO:0045621 [positive regulation of lymphocyte differentiation]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048821 [erythrocyte development]
GO:0050853 [B cell receptor signaling pathway]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0070062 [extracellular exosome]
GO:0070358 [actin polymerization-dependent cell motility]
GO:0090023 [positive regulation of neutrophil chemotaxis]
Show all
 1077 aa
122.5 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.