Fields »
ABOUT
HELP
BLOG
MMP19

GENERAL INFORMATION

Gene name

 MMP19

Gene description

 Matrix metallopeptidase 19

Protein class

 Enzymes
FDA approved drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (BEWO)
HPA (normal tissue):Tissue enhanced (adipose tissue, gallbladder)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MMP19 (HGNC Symbol)

Synonyms

 MMP18, RASI-1

Description

 Matrix metallopeptidase 19 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

Chromosome

 12

Cytoband

 q13.2

Chromosome location (bp)

 55835433 - 55842966

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123342 (version 83.38)

Entrez gene

 4327

UniProt

 Q99542 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99542

Antibodypedia

 MMP19 antibodies

PROTEIN BROWSER
MMP19-001
MMP19-005
MMP19-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MMP19-001
ENSP00000313437
ENST00000322569
Q99542 [Direct mapping]
Matrix metalloproteinase-19
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001542 [ovulation from ovarian follicle]
GO:0001554 [luteolysis]
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009725 [response to hormone]
GO:0022617 [extracellular matrix disassembly]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0051591 [response to cAMP]
Show all
 508 aa
57.4 kDa 		Yes 0
MMP19-005
ENSP00000386625
ENST00000409200
Q99542 [Direct mapping]
Matrix metalloproteinase-19
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
Show all
 305 aa
33.8 kDa 		Yes 0
MMP19-011
ENSP00000446979
ENST00000548629
F8W1C3 [Direct mapping]
Matrix metalloproteinase-19
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
Show all
 485 aa
54.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.